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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ceftazidime--a new extended-spectrum cephalosporin.

65 patients with serious infections, including 25 with septicaemia, were treated with ceftazidime, a new extended-spectrum cephalosporin. 80% of the infection were cured by the antibiotic. 11 of 12 infected patients who had malignant disease or were otherwise immunocompromised responded satisfactorily to ceftazidime; 7 of these 12 had infections caused by Pseudomonas aeruginosa. The serum half-life of ceftazidime was 1.9 h in a patient with normal renal function. After a 1 g intravenous dose the antibiotic was present in pus, sputum, and bile in therapeutic concentrations. The antibiotics should prove a useful and non-toxic alternative to the aminoglycosides.[1]


  1. Ceftazidime--a new extended-spectrum cephalosporin. Gozzard, D.I., Geddes, A.M., Farrell, I.D., Eykyn, S.J., Phillips, I., Wise, R., Brown, R.M. Lancet (1982) [Pubmed]
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