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Purcell, R.H. et al.

Modification of chronic hepatitis-B virus infection in chimpanzees by administration of an interferon inducer.

Chimpanzees chronically infected with hepatitis-B virus showed transient changes in several markers of infection when treated with the interferon inducer polyriboinosinic-polyribocytidylic acid-poly-l-lysine carboxymethyl cellulose. Serum Dane-particle-associated D.N.A. polymerase, e antigen and hepatitis-B surface antigen, and intrahepatic hepatitis-B surface and core antigens diminished during treatment. Defective (D.N.A.-polymerase-negative) Dane particles increased in titre transiently during treatment; these may play a role in the modulation of hepatitis-B virus infection. Humoral immune responses in chronic hepatitis-B carrier chimps were unaffected. Interferon inducers (or exogenous interferon) may be useful for the treatment of chronic hepatitis-B virus infection.[1]

References

Modification of chronic hepatitis-B virus infection in chimpanzees by administration of an interferon inducer. Purcell, R.H., London, W.T., McAuliffe, V.J., Palmer, A.E., Kaplan, P.M., Gerin, J.L., Wagner, J., Popper, H., Lvovsky, E., Wong, D.C., Levy, H.B. Lancet (1976) [Pubmed]

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