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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Beta adrenoceptors of human red blood cells, determination of their subtypes.

The characteristics of beta adrenergic receptors of human erythrocyte membranes were investigated using (-)125iodocyanopindolol as a radioligand. Inhibition of (-)125iodocyanopindolol specific binding was checked using either atenolol and metoprolol as beta 1 selective antagonists or ICI 118551 and IPS 339 as beta 2 selective antagonists. The results showed non linear Hofstee's plots suggesting that both beta 1 and beta 2 adrenergic receptors are present. Analysis of the data yielded a beta 1/beta 2 adrenergic receptor ratio of approximately 33/67. Thus it is concluded that beta 2 subtype is predominant on human erythrocyte membranes.[1]

References

  1. Beta adrenoceptors of human red blood cells, determination of their subtypes. Bree, F., Gault, I., d'Athis, P., Tillement, J.P. Biochem. Pharmacol. (1984) [Pubmed]
 
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