Gene Review:
ADRB2 - adrenoceptor beta 2, surface
Homo sapiens
Synonyms:
ADRB2R, ADRBR, B2AR, BAR, BETA2AR, ...
Landau,
Morales,
Antonarakis,
Blouin,
Smiley,
Herrmann,
Nicaud,
Tiret,
Evans,
Kee,
Ruidavets,
Arveiler,
Luc,
Morrison,
Hoehe,
Paul,
Cambien,
Taylor,
Epton,
Kennedy,
Smith,
Iles,
Miller,
Littlejohn,
Cowan,
Hewitt,
Swanney,
Brassett,
Herbison,
Masuo,
Katsuya,
Fu,
Rakugi,
Ogihara,
Tuck,
Gurguis,
Andrews,
Antai-Otong,
Vo,
Blakeley,
Orsulak,
Rush,
Diatchenko,
Anderson,
Slade,
Fillingim,
Shabalina,
Higgins,
Sama,
Belfer,
Goldman,
Max,
Weir,
Maixner,
van Rossum,
Hoebee,
Seidell,
Bouchard,
van Baak,
de Groot,
Chagnon,
de Graaf,
Saris,
Gurguis,
Blakeley,
Antai-Otong,
Vo,
Orsulak,
Petty,
Rush,
McCaffery,
Pogue-Geile,
Ferrell,
Petro,
Manuck,
- Polymorphisms of the beta2 -adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studies. Herrmann, S.M., Nicaud, V., Tiret, L., Evans, A., Kee, F., Ruidavets, J.B., Arveiler, D., Luc, G., Morrison, C., Hoehe, M.R., Paul, M., Cambien, F. J. Hypertens. (2002)
- Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. Sugaya, K., Nishijima, S., Yamada, T., Miyazato, M., Hatano, T., Ogawa, Y. J. Urol. (2002)
- Influence of the beta2-adrenergic receptor Arg16Gly polymorphism on longitudinal changes in obesity from childhood through young adulthood in a biracial cohort: the Bogalusa Heart Study. Ellsworth, D.L., Coady, S.A., Chen, W., Srinivasan, S.R., Elkasabany, A., Gustat, J., Boerwinkle, E., Berenson, G.S. Int. J. Obes. Relat. Metab. Disord. (2002)
- Genetic factors as predictors of weight gain in young adult Dutch men and women. van Rossum, C.T., Hoebee, B., Seidell, J.C., Bouchard, C., van Baak, M.A., de Groot, C.P., Chagnon, M., de Graaf, C., Saris, W.H. Int. J. Obes. Relat. Metab. Disord. (2002)
- The 27Glu polymorphism of the beta2-adrenergic receptor gene interacts with physical activity influencing obesity risk among female subjects. Corbalán, M.S., Marti, A., Forga, L., Martínez-González, M.A., Martínez, J.A. Clin. Genet. (2002)
- Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Diatchenko, L., Anderson, A.D., Slade, G.D., Fillingim, R.B., Shabalina, S.A., Higgins, T.J., Sama, S., Belfer, I., Goldman, D., Max, M.B., Weir, B.S., Maixner, W. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2006)
- Neutrophil beta2-adrenergic receptor coupling efficiency to Gs protein in subjects with post-traumatic stress disorder and normal controls. Gurguis, G.N., Andrews, R., Antai-Otong, D., Vo, S.P., Blakeley, J.E., Orsulak, P.J., Rush, A.J. Psychopharmacology (Berl.) (1999)
- Adrenergic receptor function in panic disorder. II. Neutrophil beta 2 receptors: Gs protein coupling, effects of imipramine treatment and relationship to treatment outcome. Gurguis, G.N., Blakeley, J.E., Antai-Otong, D., Vo, S.P., Orsulak, P.J., Petty, F., Rush, A.J. Journal of psychiatric research. (1999)
- Adrenergic receptors in premenstrual dysphoric disorder. II. Neutrophil beta2-adrenergic receptors: Gs protein coupling, phase of menstrual cycle and prediction of luteal phase symptom severity. Gurguis, G.N., Yonkers, K.A., Blakeley, J.E., Phan, S.P., Williams, A., Rush, A.J. Psychiatry research. (1998)
- The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. Dishy, V., Sofowora, G.G., Xie, H.G., Kim, R.B., Byrne, D.W., Stein, C.M., Wood, A.J. N. Engl. J. Med. (2001)
- A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. Simons, F.E. N. Engl. J. Med. (1997)
- Identification of a Gs activator region of the beta 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation. Okamoto, T., Murayama, Y., Hayashi, Y., Inagaki, M., Ogata, E., Nishimoto, I. Cell (1991)
- Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese. Huang, G., Xing, H., Hao, K., Peng, S., Wu, D., Guang, W., Huang, A., Hong, X., Wang, Y., Feng, Y., Zhang, Y., Li, J., Chen, C., Wang, B., Zhang, X., Li, D., Yu, Y., Liu, J., Zhu, G., Huo, Y., Chen, D., Hou, Y., Wang, X., Xu, X., Niu, T., Xu, X. Clin. Exp. Hypertens. (2004)
- Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. Lohse, M.J., Lefkowitz, R.J., Caron, M.G., Benovic, J.L. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Metabolic and calorigenic effects of dopexamine in healthy volunteers. Geisser, W., Träger, K., Hähn, A., Georgieff, M., Ensinger, H. Crit. Care Med. (1997)
- Beta2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals. Masuo, K., Katsuya, T., Fu, Y., Rakugi, H., Ogihara, T., Tuck, M.L. Am. J. Hypertens. (2005)
- Disodium cromoglycate does not prevent terbutaline-induced desensitization of beta 2-adrenoceptor-mediated cardiovascular in vivo functions in human volunteers. Schäfers, R.F., Piest, U., von Birgelen, C., Jakubetz, J., Daul, A.E., Philipp, T., Brodde, O.E. J. Cardiovasc. Pharmacol. (1999)
- Arg16 homozygosity of the beta2-adrenergic receptor improves the outcome after beta2-agonist tocolysis for preterm labor. Landau, R., Morales, M.A., Antonarakis, S.E., Blouin, J.L., Smiley, R.M. Clin. Pharmacol. Ther. (2005)
- Bronchodilator response in relation to beta2-adrenoceptor haplotype in patients with asthma. Taylor, D.R., Epton, M.J., Kennedy, M.A., Smith, A.D., Iles, S., Miller, A.L., Littlejohn, M.D., Cowan, J.O., Hewitt, T., Swanney, M.P., Brassett, K.P., Herbison, G.P. Am. J. Respir. Crit. Care Med. (2005)
- Variability within alpha- and beta-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge. McCaffery, J.M., Pogue-Geile, M.F., Ferrell, R.E., Petro, N., Manuck, S.B. J. Hypertens. (2002)
- Polymorphism of beta-adrenergic receptors and susceptibility to open-angle glaucoma. Inagaki, Y., Mashima, Y., Fuse, N., Funayama, T., Ohtake, Y., Yasuda, N., Murakami, A., Hotta, Y., Fukuchi, T., Tsubota, K. Mol. Vis. (2006)
- A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Cao, T.T., Deacon, H.W., Reczek, D., Bretscher, A., von Zastrow, M. Nature (1999)
- Coexistence of functioning beta 1- and beta 2-adrenoceptors in single myocytes from human ventricle. del Monte, F., Kaumann, A.J., Poole-Wilson, P.A., Wynne, D.G., Pepper, J., Harding, S.E. Circulation (1993)
- Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. Oakley, R.H., Laporte, S.A., Holt, J.A., Barak, L.S., Caron, M.G. J. Biol. Chem. (2001)
- Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Thaker, P.H., Han, L.Y., Kamat, A.A., Arevalo, J.M., Takahashi, R., Lu, C., Jennings, N.B., Armaiz-Pena, G., Bankson, J.A., Ravoori, M., Merritt, W.M., Lin, Y.G., Mangala, L.S., Kim, T.J., Coleman, R.L., Landen, C.N., Li, Y., Felix, E., Sanguino, A.M., Newman, R.A., Lloyd, M., Gershenson, D.M., Kundra, V., Lopez-Berestein, G., Lutgendorf, S.K., Cole, S.W., Sood, A.K. Nat. Med. (2006)
- Basal fat oxidation and after a peak oxygen consumption test in obese women with a beta2 adrenoceptor gene polymorphism. Macho-Azcarate, T., Marti, A., Calabuig, J., Martinez, J.A. J. Nutr. Biochem. (2003)
- The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation. Eason, M.G., Jacinto, M.T., Theiss, C.T., Liggett, S.B. Proc. Natl. Acad. Sci. U.S.A. (1994)
- A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Hall, R.A., Ostedgaard, L.S., Premont, R.T., Blitzer, J.T., Rahman, N., Welsh, M.J., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (1998)
- c-Src tyrosine kinase binds the beta 2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization. Fan , G., Shumay, E., Malbon, C.C., Wang , H. J. Biol. Chem. (2001)
- Iodinated analogs of trimetoquinol as highly potent and selective beta 2-adrenoceptor ligands. De Los Angeles, J.E., Nikulin, V.I., Shams, G., Konkar, A.A., Mehta, R., Feller, D.R., Miller, D.D. J. Med. Chem. (1996)
- Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor. Tao, J., Wang, H.Y., Malbon, C.C. EMBO J. (2003)
- Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. Ménard, L., Ferguson, S.S., Barak, L.S., Bertrand, L., Premont, R.T., Colapietro, A.M., Lefkowitz, R.J., Caron, M.G. Biochemistry (1996)
- The beta-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase. Baltensperger, K., Karoor, V., Paul, H., Ruoho, A., Czech, M.P., Malbon, C.C. J. Biol. Chem. (1996)
- The beta-adrenergic receptor kinase (GRK2) is regulated by phospholipids. Onorato, J.J., Gillis, M.E., Liu, Y., Benovic, J.L., Ruoho, A.E. J. Biol. Chem. (1995)
- RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells. Lynch, M.J., Baillie, G.S., Mohamed, A., Li, X., Maisonneuve, C., Klussmann, E., van Heeke, G., Houslay, M.D. J. Biol. Chem. (2005)
- Beta 2-adrenergic receptor agonist induces IL-18 production without IL-12 production. Takahashi, H.K., Iwagaki, H., Mori, S., Yoshino, T., Tanaka, N., Nishibori, M. J. Neuroimmunol. (2004)
- Selective regulation of beta 2-adrenergic receptor gene expression by interleukin-1 in cultured human lung tumor cells. Szentendrei, T., Lazar-Wesley, E., Nakane, T., Virmani, M., Kunos, G. J. Cell. Physiol. (1992)
- beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Premont, R.T., Claing, A., Vitale, N., Freeman, J.L., Pitcher, J.A., Patton, W.A., Moss, J., Vaughan, M., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (1998)
- A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration. Green, S.A., Liggett, S.B. J. Biol. Chem. (1994)
- Cloning of the cDNA for the human beta 1-adrenergic receptor. Frielle, T., Collins, S., Daniel, K.W., Caron, M.G., Lefkowitz, R.J., Kobilka, B.K. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. Benovic, J.L., Gomez, J. J. Biol. Chem. (1993)
- Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. Fredericks, Z.L., Pitcher, J.A., Lefkowitz, R.J. J. Biol. Chem. (1996)
- Lack of beta 3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human. Thomas, R.F., Liggett, S.B. Mol. Pharmacol. (1993)
- Polymorphisms of IL4, IL13, and ADRB2 genes in COPD. Hegab, A.E., Sakamoto, T., Saitoh, W., Massoud, H.H., Massoud, H.M., Hassanein, K.M., Sekizawa, K. Chest (2004)
- Relation of beta(2)-Adrenoceptor Haplotype to Risk of Death and Heart Transplantation in Patients With Heart Failure. Shin, J., Lobmeyer, M.T., Gong, Y., Zineh, I., Langaee, T.Y., Yarandi, H., Schofield, R.S., Aranda, J.M., Hill, J.A., Pauly, D.F., Johnson, J.A. Am. J. Cardiol. (2007)
- ADRB2 polymorphisms and asthma susceptibility: transmission disequilibrium test and meta-analysis. Migita, O., Noguchi, E., Jian, Z., Shibasaki, M., Migita, T., Ichikawa, K., Matsui, A., Arinami, T. Int. Arch. Allergy Immunol. (2004)