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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Selective stimulation of the synthesis of an 80,000-dalton protein by calcium ionophores.

Brief exposure of cultured chicken pectoralis muscle cells to ionomycin or A23187 selectively increases the rate of incorporation of [35S]methionine into an 80,000-dalton protein was also observed upon cell-free translation of poly(A)-enriched RNA isolated from ionomycin-treated, as compared with control, cultures. These observations suggest that ionomycin selectively increases the cellular concentration of mRNA, which codes for the 80,000-dalton protein. The effect is probably mediated through an increase in cytoplasmic [Ca2+] caused by the ionophore. A similar effect of ionomycin was observed in cultured fibroblasts, HeLa cells, mouse LSP cells, and monkey kidney CV1 cells.[1]

References

  1. Selective stimulation of the synthesis of an 80,000-dalton protein by calcium ionophores. Wu, F.S., Park, Y.C., Roufa, D., Martonosi, A. J. Biol. Chem. (1981) [Pubmed]
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