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Potential of liquid membranes for drug overdose treatment: in vitro studies.

The in vitro removal of six barbiturates from pH 2 donor solutions by liquid membranes with pH control was evaluated. More than 90% of amorbarbital, phenobarbital, and secobarbital were removed within 10 min by the liquid membranes. Drug transport obeyed first-order kinetics initially, and Fick's law was obeyed. The transport rate of phenobarbital by a liquid membrane was temperature dependent. An Arrhenius plot revealed that the activation energy was 10 kcal/mole. The liquid membranes showed some instability in the presence of bile salts.[1]

References

  1. Potential of liquid membranes for drug overdose treatment: in vitro studies. Chiang, C.W., Fuller, G.C., Frankenfeld, J.W., Rhodes, C.T. Journal of pharmaceutical sciences. (1978) [Pubmed]
 
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