Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Loesch, A.

The neurohypophysial axons in normal and dehydrated rats: an electron microscopic study including ZIO-staining method.

The neurohypophysial axons from normal rats and those dehydrated for 4 and 12 days were investigated by means of conventional glutaraldehyde fixation and the zinc-iodide-osmium (ZIO) staining technique. Conventionally fixed axons from dehydrated rats revealed depletion of dense core of neurosecretory granules, more frequent occurrence of microvesicles, proliferation of smooth endoplasmic reticulum or accumulation of lysosomes. It has been disclosed that the ZIO reaction product has the ability to stain microvesicles (normal rats) and smooth endoplasmic reticulum, lysosomes, some neurosecretory granules and some parts of stromal inclusion at the release site (dehydrated rats). Quantitative data are also presented. They indicate a significantly decreased number of both neurosecretory granules (NSG) and ZIO-positive microvesicles (MV) in dehydrated rats. Equally, the value of the median of the MV/NSG ratio was significantly increased from 1.38 in normal rats to 5.50 and 7.50 in rats dehydrated for 4 and 12 days, respectively. Thus, the possible involvement of ZIO-positive microvesicles in a process associated with neurosecretion is suggested. While in normal rats a correlation was found between the number of neurosecretory granules and the area of sectioned profiles of the axons, no evidence was obtained for it in 12-day dehydrated rats. Conversely, no evidence for a relationship between the axon area and the number of ZIO-positive microvesicles was obtained in normal rats, while in rats dehydrated for 12 days a correlation was found.[1]

References

The neurohypophysial axons in normal and dehydrated rats: an electron microscopic study including ZIO-staining method. Loesch, A. The Australian journal of experimental biology and medical science. (1983) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.