Disease relevance of diiodozinc

• Early and late sarcoplasmic reticulum changes in doxorubicin cardiomyopathy. An ultrastructural investigation with the zinc iodide-osmium tetroxide (ZIO) technique [1].

High impact information on diiodozinc

• In zinc-iodide-osmium (ZIO) stained preparations, muscle fibers with small nerve terminals were present at 60 d and were still present in old muscle at 120 d [2].
• The interrelationships between these organelles are considered in view of the similarity of the ZIO localization to phosphatase-rich sites in the neuronal perikarya and with respect to the possibility that components of the synaptic vesicles are formed in the Golgi region of the cell and migrate via the axonal smooth ER to the synaptic regions [3].
• A positive response to ZIO occurs in certain Golgi vesicles and saccules, in GERL (Golgi-endoplasmic-reticulum-lysosomes), in multivesicular bodies as well as residual bodies and in small vesicles and cisternae of axonal smooth endoplasmic reticllum (ER) [3].
• The structure of the neuromuscular junctions (NMJs) and their relation to the myenteric plexus were studied by zinc iodide-osmic acid (ZIO) staining and by scanning electron microscopy in the guinea-pig esophagus [4].
• The position of the recording sites with respect to the terminal branches was determined following zinc-iodide staining of terminals. me declined with distance from the last myelin segment along individual terminal branches: in a [Ca]o of 0.35 mM, me declined by 80% over a distance of 60 micron along mature terminal branches [5].

Biological context of diiodozinc

• Retinal alterations induced by continuous light in immature rats. II. Zinc iodide-osmium tetroxide (ZIO) reactive sites in the rod outer segments [6].
• Cytochemical relationship between Golgi complex and dense-cored granules (DCGs) of small granule-containing (SGC) cells in rat superior cervical ganglia was examined in electron microscopy by zinc-iodide-osmium tetroxide (ZIO) method and by enzyme cytochemistry for thiamine pyrophosphatase (TPPase) and acid phosphatase (ACPase) [7].
• Thus, the possible involvement of ZIO-positive microvesicles in a process associated with neurosecretion is suggested [8].

Anatomical context of diiodozinc

• The whole-mount preparations with ZIO staining also demonstrated that some NMJs receive minute branches from the myenteric plexus [4].
• These results strongly suggest that ZIO reacts with -SH groups in rod outer segments [9].
• The zinc iodide-osmium tetroxide (ZIO) reaction on nerve endings in the median eminence of the rat under normal and experimental conditions [10].
• Furthermore the influence of previous incubation with cysteine on ZIO staining was studied in the rat pineal gland [11].
• These data confirm that ICC can be electively ZIO-stained and that these cells and fibroblasts are two distinct cell types, as ultrastructural and physiological reports had previously suggested [12].

Associations of diiodozinc with other chemical compounds

• For electron microscopy, the placenta pieces were fixed in 3% glutaraldehyde in 0.1 M phosphate buffer, ph 7.4, washed with phosphate buffer, put in ZIO mixture, washed in distilled water, dehydrated in graded ethanol, cleared in propylene oxide, and embedded in resin [13].
• Fine structure and stereo-images of the Golgi apparatus and endoplasmic reticulum (ER) in the subcommissural organ (SCO) cells were visualized by the application of zinc-iodide osmium tetroxide (ZIO) impregnation, conventional electron microscopy and high voltage electron microscopy (HVEM) [14].

Gene context of diiodozinc

• After ZIO impregnation, all the saccules of Golgi apparatus and some of tubular rough endoplasmic reticulum (rER) were stained [7].
• The Golgi apparatus was also reactive toward the ZIO mixture [15].
• In this respect the effect of in vitro pretreatment with -SH reagents on ZIO staining, already described in different kinds of synaptic vesicles, was studied in rod photoreceptor outer segments [11].

Analytical, diagnostic and therapeutic context of diiodozinc

• The volume density of ZIO reactive organelles increased progressively after castration, reaching significantly higher levels 21 days after castration [16].

References