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Skinner, R. et al.

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.

The enzyme which confers resistance to erythromycin in the producing organism Streptomyces erythraeus dimethylates a single adenine residue in Bacillus stearothermophilus 23 S rRNA. This corresponds to residue Ade 2058 in Escherichia coli 23 S RNA. The methylase responsible for resistance to macrolides, lincomycin, and streptogramin B-related antibiotics in Staphylococcus aureus also acts at this site.[1]

References

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics. Skinner, R., Cundliffe, E., Schmidt, F.J. J. Biol. Chem. (1983) [Pubmed]

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