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Chemical Compound Review

lincomycin     N-[2-hydroxy-1-(3,4,5- trihydroxy-6...

Synonyms: Lincomycine, AGN-PC-008PRK, CBMicro_021584, CCG-14357, SureCN12672814, ...
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Disease relevance of lincomycin


High impact information on lincomycin


Chemical compound and disease context of lincomycin


Biological context of lincomycin


Anatomical context of lincomycin

  • In four patients with continent ileostomy and malabsorption of B12, there was evidence of a stagnant loopsyndrome as oral lincomycin treatment resulted in increased absorption of B12 decreased excretion of faecal fat, and decreased concentrations of Bacteroides in the ileum [19].
  • Although photoinhibition, measured in the presence of lincomycin to block concurrent recovery, is faster in leaves of Cu(2+)-treated plants than in control leaves, thylakoids isolated from Cu-treated plants did not show high sensitivity to photoinhibition [20].
  • Nevertheless, the trimeric structure of PSI reaction center could be restored by readdition of PG, even in the presence of the protein synthesis inhibitor lincomycin, indicating that free PsaL was present in thylakoid membranes following the 21-d PG depletion [21].
  • This observation was followed up by in vitro and in vivo studies on the relation between lincomycin and meningococcal adherence to human epithelial cells [22].
  • Characterization of arabidopsis gun (genomes uncoupled) mutants, which express nuclear genes in the presence of norflurazon or lincomycin, has provided evidence for two separate signalling pathways, one involving tetrapyrrole biosynthesis intermediates and the other requiring plastid protein synthesis [23].

Associations of lincomycin with other chemical compounds


Gene context of lincomycin

  • In addition, the rate and selectivity of the D1 degradation and its dependence on the presence of lincomycin was proportional to the level of the psbA3 transcript in the particular strain [28].
  • Both plasmid encoded and chromosomally encoded TEM-1 beta-lactamase increased in the presence of lincomycin [29].
  • Escherichia coli K-12 strains isolates carrying plasmid pBR322 were grown in the presence of subinhibitory concentrations of lincomycin, which stimulated beta-lactamase synthesis about 2.5-fold, and the effects of the drug on the synthesis and degradation of bla mRNA were studied [30].
  • A gene locus (linR) responsible for the lincomycin resistance phenotype was mapped at min 30 of the Escherichia coli chromosome near tyrR; it seems to be identical to the previously described linB locus (Apirion, 1967); however, in contrast to these reports it does not seem to alter any ribosomal function [31].
  • Gene lmrB of Corynebacterium glutamicum confers efflux-mediated resistance to lincomycin [32].

Analytical, diagnostic and therapeutic context of lincomycin


  1. Clindamycin-associated colitis in hamsters: protection with vancomycin. Bartlett, J.G., Onderdonk, A.B., Cisneros, R.L. Gastroenterology (1977) [Pubmed]
  2. Prophylactic systemic antibiotics in colorectal surgery. Feathers, R.S., Sagor, G.R., Lewis, A.A., Amirak, I.D., Noone, P. Lancet (1977) [Pubmed]
  3. Lincomycin-induced cholecystitis and gallstones in guinea pigs. Scott, A.J. Gastroenterology (1976) [Pubmed]
  4. Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics. Skinner, R., Cundliffe, E., Schmidt, F.J. J. Biol. Chem. (1983) [Pubmed]
  5. Interaction of the antibiotics clindamycin and lincomycin with Escherichia coli 23S ribosomal RNA. Douthwaite, S. Nucleic Acids Res. (1992) [Pubmed]
  6. Unfavorable effect of atropine-diphenoxylate (Lomotil) therapy in lincomycin-caused diarrhea. Novak, E., Lee, J.G., Seckman, C.E., Phillips, J.P., DiSanto, A.R. JAMA (1976) [Pubmed]
  7. Sites of synthesis of chloroplast ribosomal proteins in Chlamydomonas. Schmidt, R.J., Richardson, C.B., Gillham, N.W., Boynton, J.E. J. Cell Biol. (1983) [Pubmed]
  8. Periodic variations in the ratio of free to thylakoid-bound chloroplast ribosomes during the cell cycle of Chlamydomonas reinhardtii. Chua, N.H., Blobel, G., Siekevitz, P., Palade, G.E. J. Cell Biol. (1976) [Pubmed]
  9. A New Evolutionary Variant of the Streptogramin A Resistance Protein, Vga(A)LC, from Staphylococcus haemolyticus with Shifted Substrate Specificity towards Lincosamides. Novotna, G., Janata, J. Antimicrob. Agents Chemother. (2006) [Pubmed]
  10. In-vitro comparison of macrolides, lincosamides and synergistins on Neisseria gonorrhoeae. Thabaut, A., Meyran, M., Huerre, M. J. Antimicrob. Chemother. (1985) [Pubmed]
  11. Subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain, feed efficiency, and bacterial cholyltaurine hydrolase activity. Feighner, S.D., Dashkevicz, M.P. Appl. Environ. Microbiol. (1987) [Pubmed]
  12. Adverse reactions to parenteral lincomycin. Berry, D.D., Brouhard, B.H., Box, Q.T. Pediatrics (1981) [Pubmed]
  13. Genetic analysis of acrA and lir mutations of Escherichia coli. Henson, J.M., Walker, J.R. J. Bacteriol. (1982) [Pubmed]
  14. Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11. Peschke, U., Schmidt, H., Zhang, H.Z., Piepersberg, W. Mol. Microbiol. (1995) [Pubmed]
  15. Molecular cloning and characterization of two lincomycin-resistance genes, lmrA and lmrB, from Streptomyces lincolnensis 78-11. Zhang, H.Z., Schmidt, H., Piepersberg, W. Mol. Microbiol. (1992) [Pubmed]
  16. New aspects of the kinetics of inhibition by lincomycin of peptide bond formation. Kallia-Raftopoulos, S., Kalpaxis, D.L., Coutsogeorgopoulos, C. Mol. Pharmacol. (1994) [Pubmed]
  17. Lincomycin stimulates synthesis of TEM-2 beta-lactamase by Escherichia coli. Okabe, A., Matsushita, O., Katayama, S., Hayashi, H. Antimicrob. Agents Chemother. (1986) [Pubmed]
  18. Genetic study of plasmid-associated zonal resistance to lincomycin in Streptococcus pyogenes. Malke, H., Reichardt, W., Hartmann, M., Walter, F. Antimicrob. Agents Chemother. (1981) [Pubmed]
  19. Stagnant loop syndrome in patients with continent ileostomy (intra-abdominal ileal reservoir). Schjonsby, H., Halvorsen, J.F., Hofstad, T., Hovdenak, N. Gut (1977) [Pubmed]
  20. Excess copper predisposes photosystem II to photoinhibition in vivo by outcompeting iron and causing decrease in leaf chlorophyll. Pätsikkä, E., Kairavuo, M., Sersen, F., Aro, E.M., Tyystjärvi, E. Plant Physiol. (2002) [Pubmed]
  21. Phosphatidylglycerol is essential for oligomerization of photosystem I reaction center. Domonkos, I., Malec, P., Sallai, A., Kovács, L., Itoh, K., Shen, G., Ughy, B., Bogos, B., Sakurai, I., Kis, M., Strzalka, K., Wada, H., Itoh, S., Farkas, T., Gombos, Z. Plant Physiol. (2004) [Pubmed]
  22. Effect of subminimal inhibitory concentrations of antimicrobial agents on the piliation and adherence of Neisseria meningitidis. Kristiansen, B.E., Rustad, L., Spanne, O., Bjorvatn, B. Antimicrob. Agents Chemother. (1983) [Pubmed]
  23. Coordination of plastid and nuclear gene expression. Gray, J.C., Sullivan, J.A., Wang, J.H., Jerome, C.A., MacLean, D. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (2003) [Pubmed]
  24. The neurotoxicity of antibacterial agents. Snavely, S.R., Hodges, G.R. Ann. Intern. Med. (1984) [Pubmed]
  25. Populations of photoinactivated photosystem II reaction centers characterized by chlorophyll a fluorescence lifetime in vivo. Matsubara, S., Chow, W.S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  26. Mode of action of bottromycin A2. Release of aminoacyl- or peptidyl-tRNA from ribosomes. Otaka, T., Kaji, A. J. Biol. Chem. (1976) [Pubmed]
  27. Effects of genes encoding resistance to streptogramins A and B on the activity of quinupristin-dalfopristin against Enterococcus faecium. Bozdogan, B., Leclercq, R. Antimicrob. Agents Chemother. (1999) [Pubmed]
  28. Degradation of the Photosystem II D1 and D2 proteins in different strains of the cyanobacterium Synechocytis PCC 6803 varying with respect to the type and level of psbA transcript. Komenda, J., Hassan, H.A., Diner, B.A., Debus, R.J., Barber, J., Nixon, P.J. Plant Mol. Biol. (2000) [Pubmed]
  29. Effects of lincomycin on synthesis of TEM beta-lactamase by Escherichia coli. Okabe, A., Matsushita, O., Hayashi, H. J. Antibiot. (1988) [Pubmed]
  30. Lincomycin increases the half-life of beta-lactamase mRNA. Matsushita, O., Okabe, A., Hayashi, H., Kanemasa, Y. Antimicrob. Agents Chemother. (1989) [Pubmed]
  31. Analysis of lincomycin resistance mutations in Escherichia coli. Hummel, H., Piepersberg, W., Böck, A. Mol. Gen. Genet. (1979) [Pubmed]
  32. Gene lmrB of Corynebacterium glutamicum confers efflux-mediated resistance to lincomycin. Kim, H.J., Kim, Y., Lee, M.S., Lee, H.S. Mol. Cells (2001) [Pubmed]
  33. A critical role for the Var2 FtsH homologue of Arabidopsis thaliana in the photosystem II repair cycle in vivo. Bailey, S., Thompson, E., Nixon, P.J., Horton, P., Mullineaux, C.W., Robinson, C., Mann, N.H. J. Biol. Chem. (2002) [Pubmed]
  34. The spectrum of colitis associated with lincomycin and clindamycin therapy. Le Frock, J.L., Klainer, A.S., Chen, S., Gainer, R.B., Omar, M., Anderson, W. J. Infect. Dis. (1975) [Pubmed]
  35. Lincomycin increases synthetic rate and periplasmic pool size for cholera toxin. Levner, M.H., Urbano, C., Rubin, B.A. J. Bacteriol. (1980) [Pubmed]
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