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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Myelin-associated glycoprotein is produced before myelin basic protein in cultured oligodendrocytes.

Mixed glial cell cultures from neonatal dog cerebellum were harvested daily between 3 and 21 days after seeding and studied with immunocytochemical techniques for the demonstration of myelin-associated glycoprotein (MAG) and myelin basic protein ( MBP). Both MAG and MBP were detected in the cultures and by means of double labelling techniques shown to be produced by the same cells. MAG+ cells occurred earlier and were always more numerous than MBP+ cells. These results suggest that the oligodendrocyte in vitro expresses MAG before MBP. The findings are discussed in respect to oligodendroglial differentiation and myelination in vivo.[1]

References

  1. Myelin-associated glycoprotein is produced before myelin basic protein in cultured oligodendrocytes. Zurbriggen, A., Vandevelde, M., Steck, A., Angst, B. J. Neuroimmunol. (1984) [Pubmed]
 
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