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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Single-shot channel activation accounts for duration of inhibitory postsynaptic potentials in a central neuron.

In the goldfish Mauthner cell, inhibitory postsynaptic currents evoked by intracellular stimulation of presynaptic neurons decay exponentially, with a mean time constant of 6.65 milliseconds. Analysis of membrane conductance fluctuations induced by iontophoresis of glycine and gamma-aminobutyric acid indicates a mean inhibitory channel lifetime of 7.15 milliseconds. The results thus suggest that the relaxation kinetics of activated inhibitory channels are rate-limiting during decay of the inhibitory postsynaptic current.[1]

References

  1. Single-shot channel activation accounts for duration of inhibitory postsynaptic potentials in a central neuron. Faber, D.S., Korn, H. Science (1980) [Pubmed]
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