Cell cycle-specific enhancement of type C virus activation by sodium n-butyrate.
The effect of sodium n-butyrate on chemical induction of xenotropic virus from synchronized Kirsten sarcoma virus-transformed BALB mouse cells was examined. When added during the last part of the G1 phase, n-butyrate produced a large increase in cycloheximide induction during S phase. Under similar conditions, activation by 5-iododeoxyuridine was inhibited. When added with cycloheximide during the S phase, n-butyrate inhibited activation of virus. Studies with synchronized cultures showed that n-butyrate delayed the onset of DNA synthesis, characteristic of the S phase, and inhibited histone deacetylation in log-phase cells. The effects produced by n-butyrate could, therefore, be the result of lengthening the G1 phase of the cell cycle or a modification of histones affecting transcription during virus activation.[1]References
- Cell cycle-specific enhancement of type C virus activation by sodium n-butyrate. Long, C.W., Suk, W.A., Snead, R.M., Christensen, W.L. Cancer Res. (1980) [Pubmed]
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