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Chemical Compound Review

butanoic acid     butanoic acid

Synonyms: butanate, butanoate, Buttersaeure, propylformate, n-Butyric acid, ...
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Disease relevance of butanoic acid


Psychiatry related information on butanoic acid


High impact information on butanoic acid


Chemical compound and disease context of butanoic acid


Biological context of butanoic acid


Anatomical context of butanoic acid


Associations of butanoic acid with other chemical compounds


Gene context of butanoic acid

  • Quantitation of transcripts of CD86 accompanied with RNA synthesis inhibition assay and nuclear run-on assay revealed that SB up-regulates the CD86 expression transcriptionally [31].
  • Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2 mRNA remained relatively constant [32].
  • Butyric acid promoted the synthesis of hemoglobin in UT-7/Epo, but not UT-7 [33].
  • The expression of CD80, CD86, human leukocyte antigen (HLA)-DR, HLA-ABC, and intracellular adhesion molecule-1 (ICAM-1) was tested in human AML cell lines after the addition of HDACI, sodium butyrate (SB) [31].
  • Pretreatment of cells with the JNK inhibitor SP600125 attenuated the effect of butyric acid on apoptosis, whereas no effect was seen with the p38 inhibitor SB202190 or the ERK inhibitor PD98059 [34].

Analytical, diagnostic and therapeutic context of butanoic acid


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  3. Butyric acid induces apoptosis by up-regulating Bax expression via stimulation of the c-Jun N-terminal kinase/activation protein-1 pathway in human colon cancer cells. Mandal, M., Olson, D.J., Sharma, T., Vadlamudi, R.K., Kumar, R. Gastroenterology (2001) [Pubmed]
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  9. Structure of chromatin containing extensively acetylated H3 and H4. Simpson, R.T. Cell (1978) [Pubmed]
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  11. Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum. Sandvig, K., Garred, O., Prydz, K., Kozlov, J.V., Hansen, S.H., van Deurs, B. Nature (1992) [Pubmed]
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  15. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Kim, Y.B., Lee, K.H., Sugita, K., Yoshida, M., Horinouchi, S. Oncogene (1999) [Pubmed]
  16. Effect of sodium n-butyrate on induction of prostaglandin synthase activity in cloned mastocytoma P-815 2-E-6 cells. Koshihara, Y., Kawamura, M., Senshu, T., Murota, S. Biochem. J. (1981) [Pubmed]
  17. Lack of correlation between histone H4 acetylation and transcription during the Physarum cell cycle. Loidl, P., Loidl, A., Puschendorf, B., Gröbner, P. Nature (1983) [Pubmed]
  18. Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis. Leder, A., Orkin, S., Leder, P. Science (1975) [Pubmed]
  19. Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells. Plaetinck, G., Van der Heyden, J., Tavernier, J., Faché, I., Tuypens, T., Fischkoff, S., Fiers, W., Devos, R. J. Exp. Med. (1990) [Pubmed]
  20. Dimethyl sulfoxide-induced transglutaminase activity in murine-derived Friend erythroleukemia cells. Hsu, K.H., Friedman, H. J. Natl. Cancer Inst. (1983) [Pubmed]
  21. The human colonic monocarboxylate transporter Isoform 1: its potential importance to colonic tissue homeostasis. Cuff, M., Dyer, J., Jones, M., Shirazi-Beechey, S. Gastroenterology (2005) [Pubmed]
  22. Persistent repression of a functional allele can be responsible for galactosyltransferase deficiency in Tn syndrome. Thurnher, M., Rusconi, S., Berger, E.G. J. Clin. Invest. (1993) [Pubmed]
  23. Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. Jordan, N.J., Kolios, G., Abbot, S.E., Sinai, M.A., Thompson, D.A., Petraki, K., Westwick, J. J. Clin. Invest. (1999) [Pubmed]
  24. Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures. Teti, A., Blair, H.C., Schlesinger, P., Grano, M., Zambonin-Zallone, A., Kahn, A.J., Teitelbaum, S.L., Hruska, K.A. J. Clin. Invest. (1989) [Pubmed]
  25. Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and IEC 18 cells. Ren, H., Musch, M.W., Kojima, K., Boone, D., Ma, A., Chang, E.B. Gastroenterology (2001) [Pubmed]
  26. Macrophage-mediated natural cytotoxicity of dimethyl sulfoxide-treated Friend erythroleukemia cells. Hsu, K.H., Friedman, H. J. Natl. Cancer Inst. (1985) [Pubmed]
  27. Effects of differing concentrations of sodium butyrate on 1,2-dimethylhydrazine-induced rat intestinal neoplasia. Freeman, H.J. Gastroenterology (1986) [Pubmed]
  28. LeProT1, a transporter for proline, glycine betaine, and gamma-amino butyric acid in tomato pollen. Schwacke, R., Grallath, S., Breitkreuz, K.E., Stransky, E., Stransky, H., Frommer, W.B., Rentsch, D. Plant Cell (1999) [Pubmed]
  29. Transient inhibition of initiation of S-phase associated with dimethyl sulfoxide induction of murine erythroleukemia cells to erythroid differentiation. Terada, M., Fried, J., Nudel, U., Rifkind, R.A., Marks, P.A. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  30. Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. Smith, R.D., Li, J., Noguchi, C.T., Schechter, A.N. Blood (2000) [Pubmed]
  31. Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells. Maeda, T., Towatari, M., Kosugi, H., Saito, H. Blood (2000) [Pubmed]
  32. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Zon, L.I., Yamaguchi, Y., Yee, K., Albee, E.A., Kimura, A., Bennett, J.C., Orkin, S.H., Ackerman, S.J. Blood (1993) [Pubmed]
  33. Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7. Komatsu, N., Yamamoto, M., Fujita, H., Miwa, A., Hatake, K., Endo, T., Okano, H., Katsube, T., Fukumaki, Y., Sassa, S. Blood (1993) [Pubmed]
  34. Cellular events involved in butyric acid-induced T cell apoptosis. Kurita-Ochiai, T., Amano, S., Fukushima, K., Ochiai, K. J. Immunol. (2003) [Pubmed]
  35. In vivo butyrate metabolism and colonic permeability in extensive ulcerative colitis. Den Hond, E., Hiele, M., Evenepoel, P., Peeters, M., Ghoos, Y., Rutgeerts, P. Gastroenterology (1998) [Pubmed]
  36. Endocytosis and intracellular transport of the glycolipid-binding ligand Shiga toxin in polarized MDCK cells. Sandvig, K., Prydz, K., Ryd, M., van Deurs, B. J. Cell Biol. (1991) [Pubmed]
  37. Role of the plasma membrane proton pump in pH regulation in non-animal cells. Sanders, D., Hansen, U.P., Slayman, C.L. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  38. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. Chao, C.C., Hu, S., Molitor, T.W., Shaskan, E.G., Peterson, P.K. J. Immunol. (1992) [Pubmed]
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