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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mast cell restoration. A study of the rat peritoneal mast cells after depletion with polymyxin B.

The recovery of mast cells in adult rats after depletion induced by polymyxin-B has been studied. At days 17-18 after depletion the number of identifiable mast cells in the peritoneal fluid reached 3 X 10(6) cells/rat. Mast cell granule constituents such as histamine, heparin, mast cell protease and beta-glucuronidase increased steadily during the observation period, whereas the amount of N-acetyl-beta-glucosaminidase decreased during the first 2 weeks and was thereafter constant. At 2 weeks after depletion the peritoneal mast cells were biochemically restored. From 14 to 34 days (end of experimental period) cell growth occurred with a simultaneous accumulation of the various mast cell granule constituents.[1]

References

  1. Mast cell restoration. A study of the rat peritoneal mast cells after depletion with polymyxin B. Krüger, P.G., Lagunoff, D. Int. Arch. Allergy Appl. Immunol. (1981) [Pubmed]
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