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Gene Review

Hexa  -  hexosaminidase A

Rattus norvegicus

Synonyms: Beta-N-acetylhexosaminidase subunit alpha, Beta-hexosaminidase subunit alpha, Hexosaminidase subunit A, N-acetyl-beta-glucosaminidase subunit alpha
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Disease relevance of Hexa

  • After 6 or 12 weeks of hypertension, specific activities of all enzymes measured were significantly increased, levels ranging from 24% above normal for cathepsin C to 351% above normal for N-acetyl-beta-glucosaminidase [1].
  • When homogenates of rat liver and hepatomas were centrifuged at 78 000 X g, over 90% of liver N-acetylglucosaminyltransferase assayed with beta-galactosidase- and beta-N-acetylhexosaminidase-treated asialofetuin as acceptor was recovered in the particulate fraction, while as much as 24% of hepatoma transferase was in the supernatant fraction [2].

High impact information on Hexa


Biological context of Hexa

  • The use of urinary N-acetyl-beta-glucosaminidase in human renal toxicology. I. Partial biochemical characterization and excretion in humans and release from the isolated perfused rat kidney [7].

Anatomical context of Hexa


Associations of Hexa with chemical compounds


Other interactions of Hexa

  • Somatostatin mRNA concentrations were significantly higher in the hypothalami of older rats and administration of Hexa for 30 or 60 days brought the concentrations of somatostatin mRNA of aged rats to 'young' levels [12].
  • To analyze transcription levels of Hex alpha and beta subunits (Hexa and Hexb, respectively), real-time relative quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis was performed using the LightCycler system [17].

Analytical, diagnostic and therapeutic context of Hexa


  1. Hydrolase activities in the rat aorta. II. Effects of hypertension alone and in combination with diabetes mellitus. Wolinsky, H., Capron, L., Goldfischer, S., Capron, F., Coltoff-Schiller, B., Kasak, L.E. Circ. Res. (1978) [Pubmed]
  2. Studies on UDP-N-acetylglucosamine : alpha-mannoside beta-N-acetylglucosaminyltransferase of rat liver and hepatomas. Miyagi, T., Tsuiki, S. Biochim. Biophys. Acta (1981) [Pubmed]
  3. Delivery of hexosaminidase A to the cerebrum after osmotic modification of the blood--brain barrier. Neuwelt, E.A., Barranger, J.A., Brady, R.O., Pagel, M., Furbish, F.S., Quirk, J.M., Mook, G.E., Frenkel, E. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  4. Hydrolase activities in the rat aorta. III. Effects of regular swimming activity and its cessation. Wolinsky, H., Goldfischer, S., Katz, D., Markle, R., Gidez, L., Wassertheil-Smoller, S., Coltoff-Schiller, B. Circ. Res. (1979) [Pubmed]
  5. Delivery of active hexosaminidase across the blood-brain barrier in rats. Neuwelt, E.A., Barranger, J.A., Pagel, M.A., Quirk, J.M., Brady, R.O., Frenkel, E.P. Neurology (1984) [Pubmed]
  6. Hexa- and pentapeptide extension of proalbumin: feedback inhibition of albumin synthesis by its propeptide in isolated hepatocytes and in the cell-free system. Weigand, K., Schmid, M., Villringer, A., Birr, C., Heinrich, P.C. Biochemistry (1982) [Pubmed]
  7. The use of urinary N-acetyl-beta-glucosaminidase in human renal toxicology. I. Partial biochemical characterization and excretion in humans and release from the isolated perfused rat kidney. Lockwood, T.D., Bosmann, H.B. Toxicol. Appl. Pharmacol. (1979) [Pubmed]
  8. Intracellular localization of estramustine in rat ventral prostate in vitro. Peterson, C., Björk, P., Forsgren, B., Högberg, B. Prostate (1981) [Pubmed]
  9. Activity of N-acetyl-beta-glucosaminidase in lymphocytes of rats exposed to mixture of nitrogen oxides and chlorine. Starek, A., Moszczyński, P., Kieć, E.F. Arch. Toxicol. (1979) [Pubmed]
  10. IL-11 pretreatment reduces cell death after intestinal ischemia-reperfusion. Kuenzler, K.A., Pearson, P.Y., Schwartz, M.Z. J. Surg. Res. (2002) [Pubmed]
  11. Mast cell restoration. A study of the rat peritoneal mast cells after depletion with polymyxin B. Krüger, P.G., Lagunoff, D. Int. Arch. Allergy Appl. Immunol. (1981) [Pubmed]
  12. Effect of long-term administration of Hexarelin on the somatotrophic axis in aged rats. Cattaneo, L., Luoni, M., Settembrini, B., Müller, E.E., Cocchi, D. Pharmacol. Res. (1997) [Pubmed]
  13. Effect of epidermal growth factor on collagen formation in liver-derived epithelial clone cells. Kumegawa, M., Hiramatsu, M., Yajima, T., Hatakeyama, K., Hosoda, S., Namba, M. Endocrinology (1982) [Pubmed]
  14. Effect of peritoneal dialysis on renal morphology and function. Breborowicz, A., Pawlaczyk, K., Polubinska, A., G??rna, K., Wieslander, A., Carlsson, O., Tam, P., Wu, G. Nephrol. Dial. Transplant. (2006) [Pubmed]
  15. Comments on the cytochemical techniques using naphthol AS-BI substrates and hexazonium pararosanilin for the demonstration of acid phosphatase, beta-glucuronidase and N-acetyl-beta-glucosaminidase activities. Hayashi, M. J. Histochem. Cytochem. (1977) [Pubmed]
  16. Inability of dimethyl sulfoxide and 5-fluorouracil to open the blood-brain barrier. Neuwelt, E.A., Barnett, P., Barranger, J., McCormick, C., Pagel, M., Frenkel, E. Neurosurgery (1983) [Pubmed]
  17. Hexosaminidase-altered aberrant crypts, carrying decreased hexosaminidase alpha and beta subunit mRNAs, in colon of 1,2-dimethylhydrazine-treated rats. Tsukamoto, T., Fukami, H., Yamanaka, S., Yamaguchi, A., Nakanishi, H., Sakai, H., Aoki, I., Tatematsu, M. Jpn. J. Cancer Res. (2001) [Pubmed]
  18. Testosterone and 6-N,2'-O-dibutyryladenosine 3':5'-cyclic monophosphate stimulate protein and lysosomal enzyme secretion in rat seminal vesicle. Koenig, H., Lu, C.Y., Bakay, R. Biochem. J. (1976) [Pubmed]
  19. Lysosomal enzymes in hepatic injury induced by bromobenzene. Luoma, P.V., Guzelian, P.S. Arch. Toxicol. Suppl. (1978) [Pubmed]
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