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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Lidocaine, monoethylglycinexylidide, and isolated human uterine muscle.

The effects of lidocaine and its primary metabolite monoethylglycinexylidide (MEGX) on isolated human muscle strips from non-gravid and gravid uteri were evaluated. No differences between the effects of lidocaine and those of MEGX on gravid and non-gravid muscle strips were observed. Lidocaine produced significant (P less than 0.01) dose-related depression of uterine contractility, although significant pharamacologic depression occurred only at lidocaine concentrations in excess of 25 microgram/ml. MEGX produced no consistent changes in any of the responses measured.[1]

References

  1. Lidocaine, monoethylglycinexylidide, and isolated human uterine muscle. Munson, E.S., Embro, W.J. Anesthesiology (1978) [Pubmed]
 
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