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Rottenberg, H. et al.

Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs.

Membrane binding of ethanol, anesthetics, and hydrophobic molecules in brain synaptosomes and liver mitochondria from rats is conspicuously reduced after long-term consumption of ethanol. The membranes are resistant to structural disordering by both ethanol and halothane. Tolerance, cross-tolerance, and dependence in chronic alcoholics may in part result from membrane alterations that inhibit the binding of ethanol and other drugs.[1]

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Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs. Rottenberg, H., Waring, A., Rubin, E. Science (1981) [Pubmed]

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