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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Lithium increases serotonin release and decreases serotonin receptors in the hippocampus.

The effects of long-term lithium administration on pre- and postsynaptic processes involved in serotonergic neurotransmission were measured in rat hippocampus and cerebral cortex. Long-term lithium administration increased both basal and potassium chloride-stimulated release of endogenous serotonin from the hippocampus but not from the cortex. Serotonergic receptor binding was reduced in the hippocampus but not in the cortex. These results suggest a mechanism by which lithium may stabilize serotonin neurotransmission.[1]

References

  1. Lithium increases serotonin release and decreases serotonin receptors in the hippocampus. Treiser, S.L., Cascio, C.S., O'Donohue, T.L., Thoa, N.B., Jacobowitz, D.M., Kellar, K.J. Science (1981) [Pubmed]
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