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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Calcium effect on generation and amplification of myokymic discharges.

Maneuvers designed to manipulate ionized calcium (Ca++) were carried out in two patients with inflammatory polyradiculoneuropathy and myokymia. Increased clinical myokymia and myokymic burst amplification occurred when ionized Ca++ was lowered by plasma exchange or hyperventilation. Increasing ionized Ca++ (by intravenous infusion of CaCl2) decreased the myokymia. These findings indicate that myokymic discharges are altered by changes in serum ionized Ca++ and effects on axonal excitability.[1]


  1. Calcium effect on generation and amplification of myokymic discharges. Brick, J.F., Gutmann, L., McComas, C.F. Neurology (1982) [Pubmed]
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