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MeSH Review

Plasma Exchange

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Disease relevance of Plasma Exchange


High impact information on Plasma Exchange


Chemical compound and disease context of Plasma Exchange


Biological context of Plasma Exchange

  • Treatment of RP was with nonsteroidal antiinflammatory drugs (2 of 24), steroids (13 of 24), dapsone (7 of 24), or plasma exchanges (1 of 24); no treatment was given in 8 of the 24 pregnancies [14].
  • Thus, the influence of multiple plasma exchanges on the steady-state kinetics of digoxin and digitoxin will be limited and dosage adjustment is not required, if these drugs are given after - not before - the procedure and hypoalbuminaemia is corrected [15].
  • One receptor-negative and six receptor-defective homozygotes undergoing plasma exchange or LDL apheresis every 2 weeks were studied during 2 months each on placebo and on atorvastatin 80 mg daily [16].
  • We speculate that in HUS resistant to plasma exchange or infusion, removing the kidneys eliminates a major site of vWF fragmentation, which would limit platelet activation and protect patients from the further spreading of microvascular lesions [17].
  • Multiple attempts over a period of 2 months to decrease the frequency of plasma exchange resulted in exacerbations of disease activity, indicated by increased schistocytosis, decreased hematocrit, increased serum lactate dehydrogenase, and decreased platelet counts [18].

Anatomical context of Plasma Exchange


Associations of Plasma Exchange with chemical compounds

  • Serum-AChR-antibody and clinical response were followed for 4--12 months (mean 8 months) in six M.G. patients receiving 4--25 plasma exchanges of 2--4 1 together with immunosuppressive drugs (azathioprine [2.5 mg/kg] with or without alternate-day prednisone therapy), and in seven M.G. patients on immunosuppressive drugs alone [24].
  • The supplementation of replacement solutions used during plasma exchange with calcium gluconate prevents hypocalcaemic symptoms [25].
  • Removal of tobramycin during plasma exchange therapy [26].
  • In patients examined, these abnormalities resolved upon the remission that accompanied plasma exchange and discontinuation of ticlopidine therapy [27].
  • These data demonstrated that, depending upon quantity and frequency of pheresis, partial plasma exchange using albumin replacement may cause progressive marked reduction in concentrations of immunoglobulin, complement, fibrinogen, and cholesterol [28].

Gene context of Plasma Exchange


Analytical, diagnostic and therapeutic context of Plasma Exchange


  1. Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. Hauser, S.L., Dawson, D.M., Lehrich, J.R., Beal, M.F., Kevy, S.V., Propper, R.D., Mills, J.A., Weiner, H.L. N. Engl. J. Med. (1983) [Pubmed]
  2. Control of cerebral oedema by total hepatectomy and extracorporeal liver support in fulminant hepatic failure. Rozga, J., Podesta, L., LePage, E., Hoffman, A., Morsiani, E., Sher, L., Woolf, G.M., Makowka, L., Demetriou, A.A. Lancet (1993) [Pubmed]
  3. Short-term corticosteroids then lamivudine and plasma exchanges to treat hepatitis B virus-related polyarteritis nodosa. Guillevin, L., Mahr, A., Cohen, P., Larroche, C., Queyrel, V., Loustaud-Ratti, V., Imbert, B., Hausfater, P., Roudier, J., Bielefeld, P., Petitjean, P., Smadja, D. Arthritis Rheum. (2004) [Pubmed]
  4. Corticosteroids plus pulse cyclophosphamide and plasma exchanges versus corticosteroids plus pulse cyclophosphamide alone in the treatment of polyarteritis nodosa and Churg-Strauss syndrome patients with factors predicting poor prognosis. A prospective, randomized trial in sixty-two patients. Guillevin, L., Lhote, F., Cohen, P., Jarrousse, B., Lortholary, O., Généreau, T., Léon, A., Bussel, A. Arthritis Rheum. (1995) [Pubmed]
  5. Treatment of thrombotic thrombocytopenic purpura. Plasmapheresis, plasma transfusion, and vincristine. Sennett, M.L., Conrad, M.E. Arch. Intern. Med. (1986) [Pubmed]
  6. Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients. Bell, W.R., Braine, H.G., Ness, P.M., Kickler, T.S. N. Engl. J. Med. (1991) [Pubmed]
  7. Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis. Rogers, S.W., Andrews, P.I., Gahring, L.C., Whisenand, T., Cauley, K., Crain, B., Hughes, T.E., Heinemann, S.F., McNamara, J.O. Science (1994) [Pubmed]
  8. Successful removal of anti-phospholipid antibody during pregnancy using plasma exchange and low-dose prednisolone. Frampton, G., Cameron, J.S., Thom, M., Jones, S., Raftery, M. Lancet (1987) [Pubmed]
  9. Complications of therapeutic apheresis, including a fatal case with pulmonary vascular occlusion. Rubenstein, M.D., Wall, R.T., Wood, G.S., Edwards, M.A. Am. J. Med. (1983) [Pubmed]
  10. Treatment of steroid-unresponsive tumefactive demyelinating disease with plasma exchange. Mao-Draayer, Y., Braff, S., Pendlebury, W., Panitch, H. Neurology (2002) [Pubmed]
  11. Cyclosporine-associated thrombotic thrombocytopenic purpura following liver transplantation--successful treatment with plasma exchange. Dzik, W.H., Georgi, B.A., Khettry, U., Jenkins, R.L. Transplantation (1987) [Pubmed]
  12. Comparative effects of plasma exchange and pyridostigmine on respiratory muscle strength and breathing pattern in patients with myasthenia gravis. Goti, P., Spinelli, A., Marconi, G., Duranti, R., Gigliotti, F., Pizzi, A., Scano, G. Thorax (1995) [Pubmed]
  13. Prednisone and plasma exchange improve suppressor cell function in chronic inflammatory demyelinating polyneuropathy. De Luca, G., Lugaresi, A., Iarlori, C., Marzoli, F., Di Iorio, A., Gambi, D., Uncini, A. J. Neuroimmunol. (1999) [Pubmed]
  14. Pregnancy in relapsing polychondritis: twenty-five pregnancies in eleven patients. Papo, T., Wechsler, B., Bletry, O., Piette, A.M., Godeau, P., Piette, J.C. Arthritis Rheum. (1997) [Pubmed]
  15. Effect of plasma exchange on the steady-state kinetics of digoxin and digitoxin. Keller, F., Kreutz, G., Vöhringer, H.F., Offermann, G., Distler, A. Clinical pharmacokinetics. (1985) [Pubmed]
  16. Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia. Marais, A.D., Naoumova, R.P., Firth, J.C., Penny, C., Neuwirth, C.K., Thompson, G.R. J. Lipid Res. (1997) [Pubmed]
  17. Bilateral nephrectomy stopped disease progression in plasma-resistant hemolytic uremic syndrome with neurological signs and coma. Remuzzi, G., Galbusera, M., Salvadori, M., Rizzoni, G., Paris, S., Ruggenenti, P. Kidney Int. (1996) [Pubmed]
  18. Resolution of refractory, classic thrombotic thrombocytopenic purpura after staphylococcal protein A immunoadsorption. Drew, M.J. Transfusion (1994) [Pubmed]
  19. Glutamate receptor GluR3 antibodies and death of cortical cells. He, X.P., Patel, M., Whitney, K.D., Janumpalli, S., Tenner, A., McNamara, J.O. Neuron (1998) [Pubmed]
  20. Distal lower motor neuron syndrome with high-titer serum IgM anti-GM1 antibodies: improvement following immunotherapy with monthly plasma exchange and intravenous cyclophosphamide. Pestronk, A., Lopate, G., Kornberg, A.J., Elliott, J.L., Blume, G., Yee, W.C., Goodnough, L.T. Neurology (1994) [Pubmed]
  21. Microangiopathy following allogeneic marrow transplantation. Association with cyclosporine and methylprednisolone for graft-versus-host disease prophylaxis. Kalhs, P., Brugger, S., Schwarzinger, I., Greinix, H.T., Keil, F., Kyrle, P.A., Knöbl, P., Schneider, B., Höcker, P., Linkesch, W. Transplantation (1995) [Pubmed]
  22. Hemotherapy in patients undergoing blood group incompatible bone marrow transplantation. Lasky, L.C., Warkentin, P.I., Kersey, J.H., Ramsay, N.K., McGlave, P.B., McCullough, J. Transfusion (1983) [Pubmed]
  23. Lipoprotein lipase activity in human adipose tissue during induced hypertriglyceridaemia. Holdsworth, G., Taylor, K.G., Galton, D.J. Atherosclerosis (1979) [Pubmed]
  24. Long-term effects of repeated plasma exchange in myasthenia gravis. Newsom-Davis, J., Wilson, S.G., Vincent, A., Ward, C.D. Lancet (1979) [Pubmed]
  25. Correction of hypocalcaemic symptoms during plasma exchange. Buskard, N.A., Varghese, Z., Wills, M.R. Lancet (1976) [Pubmed]
  26. Removal of tobramycin during plasma exchange therapy. Appelgate, R., Schwartz, D., Bennett, W.M. Ann. Intern. Med. (1981) [Pubmed]
  27. Antibody inhibitors to von Willebrand factor metalloproteinase and increased binding of von Willebrand factor to platelets in ticlopidine-associated thrombotic thrombocytopenic purpura. Tsai, H.M., Rice, L., Sarode, R., Chow, T.W., Moake, J.L. Ann. Intern. Med. (2000) [Pubmed]
  28. Partial plasma exchange using albumin replacement: removal and recovery of normal plasma constituents. Orlin, J.B., Berkman, E.M. Blood (1980) [Pubmed]
  29. Severe deficiency of VWF-cleaving protease (ADAMTS13) activity defines a distinct population of thrombotic microangiopathy patients. Raife, T., Atkinson, B., Montgomery, R., Vesely, S., Friedman, K. Transfusion (2004) [Pubmed]
  30. Circulating transforming growth factor beta 1 (TGF-beta1) in Guillain-Barré syndrome: decreased concentrations in the early course and increase with motor function. Créange, A., Bélec, L., Clair, B., Degos, J.D., Raphaël, J.C., Gherardi, R.K. J. Neurol. Neurosurg. Psychiatr. (1998) [Pubmed]
  31. Comparison of von Willebrand factor antigen, von Willebrand factor-cleaving protease and protein S in blood components used for treatment of thrombotic thrombocytopenic purpura. Yarranton, H., Lawrie, A.S., Purdy, G., Mackie, I.J., Machin, S.J. Transfusion medicine (Oxford, England) (2004) [Pubmed]
  32. Removal of endotoxin and cytokines by plasma exchange in patients with acute hepatic failure. Iwai, H., Nagaki, M., Naito, T., Ishiki, Y., Murakami, N., Sugihara, J., Muto, Y., Moriwaki, H. Crit. Care Med. (1998) [Pubmed]
  33. Effect of plasma exchange on serum tissue inhibitor of metalloproteinase 1 and cytokine concentrations in patients with fulminant hepatitis. Nakamura, T., Ushiyama, C., Suzuki, S., Shimada, N., Ebihara, I., Suzaki, M., Takahashi, T., Koide, H. Blood Purif. (2000) [Pubmed]
  34. Chronic inflammatory demyelinating polyradiculoneuropathy. Mendell, J.R. Annu. Rev. Med. (1993) [Pubmed]
  35. Plasma exchange combined with azathioprine in multiple sclerosis using serial gadolinium-enhanced MRI to monitor disease activity: a randomized single-masked cross-over pilot study. Sørensen, P.S., Wanscher, B., Szpirt, W., Jensen, C.V., Ravnborg, M., Christiansen, P., Schreiber, K., Nordenbo, A. Neurology (1996) [Pubmed]
  36. Successful use of anti-CD20 monoclonal antibody (rituximab) for ABO-incompatible living-related liver transplantation. Usuda, M., Fujimori, K., Koyamada, N., Fukumori, T., Sekiguchi, S., Kawagishi, N., Akamatsu, Y., Enomoto, Y., Satoh, K., Satoh, A., Ishida, K., Moriya, T., Satomi, S. Transplantation (2005) [Pubmed]
  37. Plasma exchange in focal necrotizing glomerulonephritis without anti-GBM antibodies. Pusey, C.D., Rees, A.J., Evans, D.J., Peters, D.K., Lockwood, C.M. Kidney Int. (1991) [Pubmed]
  38. Metabolism of high density lipoprotein subfractions and constituents in Tangier disease following the infusion of high density lipoproteins. Schaefer, E.J., Anderson, D.W., Zech, L.A., Lindgren, F.T., Bronzert, T.B., Rubalcaba, E.A., Brewer, H.B. J. Lipid Res. (1981) [Pubmed]
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