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Van Meel, J.C. et al.

Effect of adrenalectomy and demedullation of the adrenals on vasopressor responses to stimulation of postjunctional alpha 2-adrenoceptors.

After adrenalectomy performed 18-12 h previously, the vasopressor responses induced by stimulation of postjunctional alpha 2-adrenoceptors (agonist: B-HT 920) were attenuated in pithed normotensive rats in contrast to pressor responses mediated by postjunctional alpha 1-adrenoceptors (agonist: cirazoline). Aldosterone and desoxycorticosterone both enhanced the vasopressor responses to the alpha 2-adrenoceptor agonist B-HT 920 in adrenalectomized rats, but did not fully restore the effects. Demedullation of the adrenals also attenuated the vasoconstrictor processes evoked by stimulation of postjunctional alpha 2-adrenoceptors 18-22 h later. This effect was reversed after an infusion with adrenaline. The combination of aldosterone and adrenaline produced full recovery of the increase in diastolic pressure elicited via alpha 2-adrenoceptors in adrenalectomized (18-22 h) animals. The results suggest that circulating adrenaline and aldosterone (or corticosterone) are required for optimal functioning of vascular postjunctional alpha 2-adrenoceptors.[1]

References

Effect of adrenalectomy and demedullation of the adrenals on vasopressor responses to stimulation of postjunctional alpha 2-adrenoceptors. Van Meel, J.C., Qian, J., Wilffert, B., De Jonge, A., Timmermans, P.B., Van Zwieten, P.A. Eur. J. Pharmacol. (1983) [Pubmed]

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