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MeSH Review


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Disease relevance of Adrenalectomy


Psychiatry related information on Adrenalectomy


High impact information on Adrenalectomy


Chemical compound and disease context of Adrenalectomy

  • A patient with advanced breast cancer who had undergone a total bilateral adrenalectomy in the past refused adrenal steroid replacement therapy with the idea that this would be the easiest and quickest way to end her life [15].
  • Despite Ang II infusion, proteinuria (17 +/- 9 mg/d) and thrombotic microangiopathy and plasma aldosterone (18 +/- 18 pg/ml) remained low but daily urinary excretion of sodium and potassium were not different from adrenalectomy + ALDO [16].
  • High plasma renin substrate concentrations, and normal basal and furosemide-stimulated plasma renin activities and plasma renin concentrations which were present before surgery, decreased after adrenalectomy, and the hypertension diminished [17].
  • RESULTS: In five patients with diabetes mellitus, glucose infusion rate required to maintain euglycemia during the clamp (mean +/- SEM) significantly improved from 27.5 +/- 6.5 micro mol/kg.min before surgery to 44.6 +/- 12.3 micro mol/kg.min 5 wk after adrenalectomy (P < 0.05) [18].
  • Extensive hormonal evaluation was performed in a girl with adrenal carcinoma during the primary tumor stage, following adrenalectomy, during the period when metastases were evident and while on treatment with o,p'-DDD [19].

Biological context of Adrenalectomy


Anatomical context of Adrenalectomy


Associations of Adrenalectomy with chemical compounds

  • Of 40 evaluable women treated with AG and hydrocortisone, 53 per cent had objective responses, as compared with 45 per cent of 29 women undergoing surgical adrenalectomy (P value not significant) [30].
  • To define further the defect in the steroid feedback mechanism in Cushing's disease, we studied the acute effects of intravenous administration of glucorticoids on plasma ACTH levels in seven patients with this disease after total adrenalectomy [31].
  • We randomized 96 postmenopausal women with metastatic breast carcinoma to receive surgical adrenalectomy or medical therapy with an adrenal inhibitor, aminoglutethimide (AG), plus replacement hydrocortisone [30].
  • In fact, after adrenalectomy, vasopressin mRNA can be detected in CRF-immunoreactive neurones [12].
  • However, adrenalectomy or dexamethasone administration did not alter the silver grain density over nuclei of intermediate lobe melanotrophs [32].

Gene context of Adrenalectomy

  • To assess whether the effect of leptin in intestinal inflammation is mediated by corticosteroids we performed adrenalectomy experiments in db/db and wild-type mice [33].
  • The increase in BDNF mRNA was mediated by a selective activation of the BDNF exon IV promoter and adrenalectomy attenuated this increase by 50% [34].
  • In wild-type mice, adrenalectomy significantly decreased AGRP mRNA but did not significantly influence POMC or NPY mRNA [35].
  • Adrenalectomy had no affect on tibial growth or plasma IGFBP-1 in these animals [36].
  • Unlike POMC, TPIT was not up-regulated by adrenalectomy in rats and did not seem down-regulated in the normal pituitary adjacent to human corticotroph microadenomas [37].

Analytical, diagnostic and therapeutic context of Adrenalectomy


  1. Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Lacroix, A., Ndiaye, N., Tremblay, J., Hamet, P. Endocr. Rev. (2001) [Pubmed]
  2. Diagnosis and treatment of primary hyperaldosteronism. Blumenfeld, J.D., Sealey, J.E., Schlussel, Y., Vaughan, E.D., Sos, T.A., Atlas, S.A., Müller, F.B., Acevedo, R., Ulick, S., Laragh, J.H. Ann. Intern. Med. (1994) [Pubmed]
  3. Cortisol suppression test in patients with elevated adrenocorticotropic hormone levels. Koletsky, R.J., Dluhy, R.G., Crantz, F.R., Williams, G.H. Ann. Intern. Med. (1982) [Pubmed]
  4. Suppression of glucocorticoid secretion and antipsychotic drugs have similar effects on the mesolimbic dopaminergic transmission. Piazza, P.V., Barrot, M., Rougé-Pont, F., Marinelli, M., Maccari, S., Abrous, D.N., Simon, H., Le Moal, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Effect of glucocorticoid replacement on tumor growth after adrenalectomy in mice. Maehara, Y., Hiramoto, Y., Akazawa, K., Sakaguchi, Y., Tamada, R., Sugimachi, K. Cancer Res. (1989) [Pubmed]
  6. The effects of adrenalectomy and corticosterone replacement on induction of maternal behavior in the virgin female rat. Rees, S.L., Panesar, S., Steiner, M., Fleming, A.S. Hormones and behavior. (2006) [Pubmed]
  7. Effects of food deprivation and adrenalectomy on CYP3A induction by RU486 in female rats. Cheesman, M.J., Mason, S.R., Reilly, P.E. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  8. Pregnancy-induced analgesia: effects of adrenalectomy and glucocorticoid replacement. Baron, S.A., Gintzler, A.R. Brain Res. (1984) [Pubmed]
  9. Taste reactivity to ethanol in rats: influence of adrenalectomy or ipsapirone. Fahlke, C., Thomasson, R., Hård, E., Engel, J.A., Hansen, S. Alcohol (1994) [Pubmed]
  10. Hypothalamic obesity after hypophysectomy or adrenalectomy: dependence on corticosterone. King, B.M., Smith, R.L. Am. J. Physiol. (1985) [Pubmed]
  11. A cyproheptadine-reversible defect in ACTH control persisting after removal of the pituitary tumor in Cushing's disease. Lankford, H.V., Tucker, H.S., Blackard, W.G. N. Engl. J. Med. (1981) [Pubmed]
  12. Co-localization of corticotropin releasing factor and vasopressin mRNA in neurones after adrenalectomy. Wolfson, B., Manning, R.W., Davis, L.G., Arentzen, R., Baldino, F. Nature (1985) [Pubmed]
  13. Relationships between brain noradrenergic activity and blood glucose. Smythe, G.A., Grunstein, H.S., Bradshaw, J.E., Nicholson, M.V., Compton, P.J. Nature (1984) [Pubmed]
  14. Brain corticosteroid receptor balance in health and disease. De Kloet, E.R., Vreugdenhil, E., Oitzl, M.S., Joëls, M. Endocr. Rev. (1998) [Pubmed]
  15. Eight-day survival without adrenal steroids. Jain, J., Arnstein, A.R., Singhakowinta, A., Vaitkevicius, V.K. JAMA (1977) [Pubmed]
  16. Aldosterone plays a pivotal role in the pathogenesis of thrombotic microangiopathy in SHRSP. Chander, P.N., Rocha, R., Ranaudo, J., Singh, G., Zuckerman, A., Stier, C.T. J. Am. Soc. Nephrol. (2003) [Pubmed]
  17. Hypertension and aldosterone overproduction without renin suppression in Cushing's syndrome from an adrenal adenoma. Guthrie, G.P., Kotchen, T.A. Am. J. Med. (1979) [Pubmed]
  18. Improvement of insulin sensitivity after adrenalectomy in patients with pheochromocytoma. Wiesner, T.D., Blüher, M., Windgassen, M., Paschke, R. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  19. Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens. Korth-Schutz, S., Levine, L.S., Roth, J.A., Saenger, P., New, M.I. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  20. The in vivo time course for elimination of adrenalectomy-induced apoptotic profiles from the granule cell layer of the rat hippocampus. Hu, Z., Yuri, K., Ozawa, H., Lu, H., Kawata, M. J. Neurosci. (1997) [Pubmed]
  21. Regulation of cell death and survival in intestinal intraepithelial lymphocytes. Brunner, T., Arnold, D., Wasem, C., Herren, S., Frutschi, C. Cell Death Differ. (2001) [Pubmed]
  22. Transcriptional and post-transcriptional regulation of L-type pyruvate kinase in diabetic rat liver by insulin and dietary fructose. Noguchi, T., Inoue, H., Tanaka, T. J. Biol. Chem. (1985) [Pubmed]
  23. Further characterization of the role of corticosterone in the loss of humoral immunity in zinc-deficient A/J mice as determined by adrenalectomy. DePasquale-Jardieu, P., Fraker, P.J. J. Immunol. (1980) [Pubmed]
  24. Effects of adrenalectomy on hormone action on hepatic glucose metabolism. Impaired glucagon activation of glycogen phosphorylase in hepatocytes from adrenalectomized rats. Chan, T.M., Steiner, K.E., Exton, J.H. J. Biol. Chem. (1979) [Pubmed]
  25. Coordinate hormonal and synaptic regulation of vasopressin messenger RNA. Baldino, F., O'Kane, T.M., Fitzpatrick-McElligott, S., Wolfson, B. Science (1988) [Pubmed]
  26. Endogenous glucocorticoids decrease the acinar cell sensitivity to apoptosis during cerulein pancreatitis in rats. Kimura, K., Shimosegawa, T., Sasano, H., Abe, R., Satoh, A., Masamune, A., Koizumi, M., Nagura, H., Toyota, T. Gastroenterology (1998) [Pubmed]
  27. Intrathecal injection of bombesin inhibits gastric acid secretion in the rat. Yang, H., Cuttitta, F., Raybould, H., Taché, Y. Gastroenterology (1989) [Pubmed]
  28. Angiotensin II receptors in paraventricular nucleus, subfornical organ, and pituitary gland of hypophysectomized, adrenalectomized, and vasopressin-deficient rats. Castrén, E., Saavedra, J.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  29. Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression. Chalmers, D.T., Kwak, S.P., Mansour, A., Akil, H., Watson, S.J. J. Neurosci. (1993) [Pubmed]
  30. A randomized trial comparing surgical adrenalectomy with aminoglutethimide plus hydrocortisone in women with advanced breast cancer. Santen, R.J., Worgul, T.J., Samojlik, E., Interrante, A., Boucher, A.E., Lipton, A., Harvey, H.A., White, D.S., Smart, E., Cox, C., Wells, S.A. N. Engl. J. Med. (1981) [Pubmed]
  31. Paradoxical ACTH response to glucocorticoids in Cushing's disease. Fehm, H.L., Voight, K.H., Lang, R.E., Beinert, K.E., Kummer, G.W., Pfeiffer, E.F. N. Engl. J. Med. (1977) [Pubmed]
  32. Regulation of pro-opiomelanocortin gene transcription in individual cell nuclei. Fremeau, R.T., Lundblad, J.R., Pritchett, D.B., Wilcox, J.N., Roberts, J.L. Science (1986) [Pubmed]
  33. Leptin mediates Clostridium difficile toxin A-induced enteritis in mice. Mykoniatis, A., Anton, P.M., Wlk, M., Wang, C.C., Ungsunan, L., Blüher, S., Venihaki, M., Simeonidis, S., Zacks, J., Zhao, D., Sougioultzis, S., Karalis, K., Mantzoros, C., Pothoulakis, C. Gastroenterology (2003) [Pubmed]
  34. Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. Funakoshi, H., Frisén, J., Barbany, G., Timmusk, T., Zachrisson, O., Verge, V.M., Persson, H. J. Cell Biol. (1993) [Pubmed]
  35. Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice. Makimura, H., Mizuno, T.M., Roberts, J., Silverstein, J., Beasley, J., Mobbs, C.V. Diabetes (2000) [Pubmed]
  36. Corticosterone regulation of insulin-like growth factor I, IGF-binding proteins, and growth in streptozotocin-induced diabetic rats. Rodgers, B.D., Strack, A.M., Dallman, M.F., Hwa, L., Nicoll, C.S. Diabetes (1995) [Pubmed]
  37. Differential regulation of proopiomelanocortin and pituitary-restricted transcription factor (TPIT), a new marker of normal and adenomatous human corticotrophs. Vallette-Kasic, S., Figarella-Branger, D., Grino, M., Pulichino, A.M., Dufour, H., Grisoli, F., Enjalbert, A., Drouin, J., Brue, T. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  38. Noradrenergic inhibition of canine gallbladder contraction and murine pancreatic secretion during stress by corticotropin-releasing factor. Lenz, H.J., Messmer, B., Zimmerman, F.G. J. Clin. Invest. (1992) [Pubmed]
  39. Inhibition of gastric acid secretion in rats and in dogs by corticotropin-releasing factor. Taché, Y., Goto, Y., Gunion, M., Rivier, J., Debas, H. Gastroenterology (1984) [Pubmed]
  40. Specific regulation by steroid hormones of the amount of type I cyclic AMP-dependent protein kinase holoenzyme. Fuller, D.J., Byus, C.V., Russell, D.H. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  41. Tissue-specific and hormonally regulated expression of a rat alpha 2u globulin gene in transgenic mice. Soares, V.d.a. .C., Gubits, R.M., Feigelson, P., Costantini, F. Mol. Cell. Biol. (1987) [Pubmed]
  42. Transcriptional and post-transcriptional regulation of L-type pyruvate kinase gene expression in rat liver. Vaulont, S., Munnich, A., Decaux, J.F., Kahn, A. J. Biol. Chem. (1986) [Pubmed]
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