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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Activation of a Qa/ Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse.

A cDNA clone corresponding to a mRNA present at elevated levels in transformed fibroblasts encodes a Qa/ Tla class I major histocompatibility complex (MHC) antigen. High levels of this mRNA are found in all tumour cells tested; the transcript can undergo alternative splicing; and a repetitive sequence within the transcription unit has the characteristics of a transposable element. The immunological implications of MHC gene activation in tumour cells are discussed.[1]

References

  1. Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse. Brickell, P.M., Latchman, D.S., Murphy, D., Willison, K., Rigby, P.W. Nature (1983) [Pubmed]
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