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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The kappa opioid receptor, ingestive behaviors and the obese mouse ( ob/ ob).

Recent studies have suggested a role for the kappa opiate receptor and its endogenous ligand, dynorphin, in the central regulation of appetite. In this study we found that the ob/ ob mouse was mildly resistant to the ability of three kappa agonists, viz, butorphanol, tifluadom, and ketocyclazocine to induce food intake. In addition, we could find no change in ir-dynorphin levels in 7 areas for the central nervous system. These findings do not provide evidence for a role of kappa opioid feeding system in the pathogenesis of obesity in the ob/ ob mouse.[1]


  1. The kappa opioid receptor, ingestive behaviors and the obese mouse (ob/ob). Morley, J.E., Levine, A.S., Gosnell, B.A., Kneip, J., Grace, M. Physiol. Behav. (1983) [Pubmed]
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