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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Expression of hepatitis B surface antigen gene in yeast.

The DNA sequence coding for hepatitis B virus surface antigen (HBsAg) was placed under control of the repressible acid phosphatase promoter of the yeast Saccharomyces cerevisiae in a plasmid capable of autonomous replication in both yeast and Escherichia coli. Yeast transformed by this plasmid synthesized up to 5 X 10(5) molecules per cell of immunologically active HBsAg polypeptide in phosphate-free medium. The HBsAg polypeptides produced in the yeast cells were assembled into 20- to 22-nm spherical or oval particles and were immunogenic.[1]


  1. Expression of hepatitis B surface antigen gene in yeast. Miyanohara, A., Toh-e, A., Nozaki, C., Hamada, F., Ohtomo, N., Matsubara, K. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
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