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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Cardiovascular and platelet effects in man of BW 245C, a stable mimic of epoprostenol (PGI2).

1 BW 245C is a stable hydantoin prostaglandin analogue with a biological action similar to epoprostenol (PGI2). 2 Intravenous BW 245C (1,2 and 4 ng kg-1 min-1) produced a progressive increase in heart rate and pulse pressure in four healthy male volunteers. 3 These changes in heart rate and pulse pressure were accompanied by reduced ex vivo platelet aggregation to submaximal concentrations of ADP. 4 In man, BW 245C has a profile of action and potency similar to PGI2. However, it has a longer duration of action than PGI2.[1]

References

  1. Cardiovascular and platelet effects in man of BW 245C, a stable mimic of epoprostenol (PGI2). Orchard, M.A., Ritter, J.M., Shepherd, G.L., Lewis, P.J. British journal of clinical pharmacology. (1983) [Pubmed]
 
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