The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

SureCN8042     5-[(1R,5S,7R,8S)-7-hydroxy-8- [(3S)-3...

Synonyms: AG-K-15051, KBioGR_000216, KBioSS_000216, AC1L3FZB, CTK1C2906, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of epoprostenol


Psychiatry related information on epoprostenol


High impact information on epoprostenol


Chemical compound and disease context of epoprostenol


Biological context of epoprostenol


Anatomical context of epoprostenol


Associations of epoprostenol with other chemical compounds


Gene context of epoprostenol


Analytical, diagnostic and therapeutic context of epoprostenol


  1. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. Hoeper, M.M., Schwarze, M., Ehlerding, S., Adler-Schuermeyer, A., Spiekerkoetter, E., Niedermeyer, J., Hamm, M., Fabel, H. N. Engl. J. Med. (2000) [Pubmed]
  2. Prostacyclin infusion in hypertension: acute hemodynamic and hormonal effects. Chaignon, M., Ruffie, M.L., Lucsko, M., Cuche, J.L., Guedon, J., O'Grady, J. N. Engl. J. Med. (1982) [Pubmed]
  3. Hemodialysis using prostacyclin instead of heparin as the sole antithrombotic agent. Zusman, R.M., Rubin, R.H., Cato, A.E., Cocchetto, D.M., Crow, J.W., Tolkoff-Rubin, N. N. Engl. J. Med. (1981) [Pubmed]
  4. Prostacyclin infusion in patients with acute myocardial infarction (preliminary report). Edhag, O., Henriksson, P., Wennmalm, A. N. Engl. J. Med. (1983) [Pubmed]
  5. Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension. Benigni, A., Gregorini, G., Frusca, T., Chiabrando, C., Ballerini, S., Valcamonico, A., Orisio, S., Piccinelli, A., Pinciroli, V., Fanelli, R. N. Engl. J. Med. (1989) [Pubmed]
  6. Acute and chronic cyclooxygenase blockage in portal-hypertensive rats: influence in nitric oxide biosynthesis. Fernández, M., García-Pagán, J.C., Casadevall, M., Mourelle, M.I., Piqué, J.M., Bosch, J., Rodés, J. Gastroenterology (1996) [Pubmed]
  7. Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial. Badesch, D.B., Tapson, V.F., McGoon, M.D., Brundage, B.H., Rubin, L.J., Wigley, F.M., Rich, S., Barst, R.J., Barrett, P.S., Kral, K.M., Jöbsis, M.M., Loyd, J.E., Murali, S., Frost, A., Girgis, R., Bourge, R.C., Ralph, D.D., Elliott, C.G., Hill, N.S., Langleben, D., Schilz, R.J., McLaughlin, V.V., Robbins, I.M., Groves, B.M., Shapiro, S., Medsger, T.A. Ann. Intern. Med. (2000) [Pubmed]
  8. Prostaglandins and ischemic heart disease. Hirsh, P.D., Campbell, W.B., Willerson, J.T., Hillis, L.D. Am. J. Med. (1981) [Pubmed]
  9. Acute and chronic effects of ethanol and its metabolites on vascular production of prostacyclin in rats. Guivernau, M., Baraona, E., Lieber, C.S. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  10. Prostacyclin and thromboxane in pregnant and nonpregnant women in response to exercise. Rauramo, I., Ilmonen, S., Viinikka, L., Ylikorkala, O. Obstetrics and gynecology. (1995) [Pubmed]
  11. Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension. McLaughlin, V.V., Genthner, D.E., Panella, M.M., Rich, S. N. Engl. J. Med. (1998) [Pubmed]
  12. Continuous intraarterial measurement of oxygenation during aerosolized prostacyclin administration in severe respiratory failure. Bein, T., Pfeifer, M., Riegger, G.A., Taeger, K. N. Engl. J. Med. (1994) [Pubmed]
  13. Evidence of prostacyclin deficiency in the syndrome of hyporeninemic hypoaldosteronism. Nadler, J.L., Lee, F.O., Hsueh, W., Horton, R. N. Engl. J. Med. (1986) [Pubmed]
  14. Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia. Lefer, A.M., Ogletree, M.L., Smith, J.B., Silver, M.J., Nicolaou, K.C., Barnette, W.E., Gasic, G.P. Science (1978) [Pubmed]
  15. Pharmacologic modulation of erythropoietin production. Fisher, J.W. Annu. Rev. Pharmacol. Toxicol. (1988) [Pubmed]
  16. Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective study. Mills, J.L., DerSimonian, R., Raymond, E., Morrow, J.D., Roberts, L.J., Clemens, J.D., Hauth, J.C., Catalano, P., Sibai, B., Curet, L.B., Levine, R.J. JAMA (1999) [Pubmed]
  17. Differential inhibition by aspirin of vascular and platelet prostaglandin synthesis in atherosclerotic patients. Weksler, B.B., Pett, S.B., Alonso, D., Richter, R.C., Stelzer, P., Subramanian, V., Tack-Goldman, K., Gay, W.A. N. Engl. J. Med. (1983) [Pubmed]
  18. The effects of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients. Bihari, D., Smithies, M., Gimson, A., Tinker, J. N. Engl. J. Med. (1987) [Pubmed]
  19. Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. FitzGerald, G.A., Smith, B., Pedersen, A.K., Brash, A.R. N. Engl. J. Med. (1984) [Pubmed]
  20. Inhaled nitric oxide for the adult respiratory distress syndrome. Rossaint, R., Falke, K.J., López, F., Slama, K., Pison, U., Zapol, W.M. N. Engl. J. Med. (1993) [Pubmed]
  21. Regulation of histamine-mediated prostacyclin synthesis in cultured human vascular endothelial cells. Baenziger, N.L., Fogerty, F.J., Mertz, L.F., Chernuta, L.F. Cell (1981) [Pubmed]
  22. Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts. Baenziger, N.L., Becherer, P.R., Majerus, P.W. Cell (1979) [Pubmed]
  23. Thromboxane biosynthesis and platelet function in type I diabetes mellitus. Alessandrini, P., McRae, J., Feman, S., FitzGerald, G.A. N. Engl. J. Med. (1988) [Pubmed]
  24. Inhibition of prostacyclin and platelet thromboxane A2 after low-dose aspirin. Preston, F.E., Whipps, S., Jackson, C.A., French, A.J., Wyld, P.J., Stoddard, C.J. N. Engl. J. Med. (1981) [Pubmed]
  25. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. Mallat, A., Préaux, A.M., Serradeil-Le Gal, C., Raufaste, D., Gallois, C., Brenner, D.A., Bradham, C., Maclouf, J., Iourgenko, V., Fouassier, L., Dhumeaux, D., Mavier, P., Lotersztajn, S. J. Clin. Invest. (1996) [Pubmed]
  26. Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. Barry, O.P., Pratico, D., Lawson, J.A., FitzGerald, G.A. J. Clin. Invest. (1997) [Pubmed]
  27. Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. Grosser, T., Fries, S., FitzGerald, G.A. J. Clin. Invest. (2006) [Pubmed]
  28. Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. Praticò, D., Tillmann, C., Zhang, Z.B., Li, H., FitzGerald, G.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  29. Modulation of endothelial cell functions by different molecular species of interleukin 1. Dejana, E., Breviario, F., Erroi, A., Bussolino, F., Mussoni, L., Gramse, M., Pintucci, G., Casali, B., Dinarello, C.A., Van Damme, J. Blood (1987) [Pubmed]
  30. Prostacyclin inhibits mobilisation of fibrinogen-binding sites on human ADP- and thrombin-treated platelets. Hawiger, J., Parkinson, S., Timmons, S. Nature (1980) [Pubmed]
  31. Epoprostenol now the focus of numerous clinical trials. Check, W.A. JAMA (1981) [Pubmed]
  32. Effect of prostacyclin on vascular capacity in the dog. Fulghum, T.G., DiMarco, J.P., Supple, E.W., Nash, I., Gendlerman, J., Eton, D.F., Newell, J.B., Zusman, R.M., Powell, W.J. J. Clin. Invest. (1985) [Pubmed]
WikiGenes - Universities