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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

In vivo formation of dopamine from 3,4-methylenedioxyphenethylamine in the rat.

Administered 1-C14-3,4-methylenedioxyphenethylamine led to the excretion of about 2% of the urinary C14 as conjugated dopamine and 3-methoxytyramine metabolites, in tranylcypromine treated rats. The amine was not excreted unchanged. The major metabolites were identified as conjugates of methylenedioxyphenylacetic acid, homovanilic acid and dihydroxyphenylacetic acid. The latter are derived by the further metabolism of conjugated methylenedioxyphenylacetic acid. Administered tranylcypromine doubled the excretion of conjugates of labeled dopamine and3-methoxytyramine. NADPH served as a cofactor for the microsomal demethylenation of the amine.[1]


  1. In vivo formation of dopamine from 3,4-methylenedioxyphenethylamine in the rat. Schweitzer, J.W., Schwartz, R., Friedhoff, A.J. Archives internationales de pharmacodynamie et de thérapie. (1978) [Pubmed]
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