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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Structure and expression of a cloned cDNA for human interleukin-2.

A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The DNA sequence codes for a polypeptide which consists of 153 amino acids including a putative signal sequence. A biologically active polypeptide, characteristic of human IL-2, was produced when the cDNA was fused to a simian virus 40 promoter sequence and used to transfect cultured monkey COS cells.[1]


  1. Structure and expression of a cloned cDNA for human interleukin-2. Taniguchi, T., Matsui, H., Fujita, T., Takaoka, C., Kashima, N., Yoshimoto, R., Hamuro, J. Nature (1983) [Pubmed]
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