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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Minimal-change nephropathy and malignant thymoma.

A 56-year-old man had fever, precordial pain, and a mediastinal mass. The mass disappeared two months later and the patient remained asymptomatic for 2 1/2 years. At that time a full-blown nephrotic syndrome developed, with minimal-change glomerulopathy. The chest x-ray film showed the reappearance of a giant mediastinal mass. On biopsy of the mass, malignant thymoma was diagnosed. Association between minimal-change disease and Hodgkin's disease is well known, while the association with malignant thymoma has not been previously reported. The relationship between malignant thymoma and minimal-change disease is discussed, and a possible pathogenic mechanism involving cell-mediated immunity is proposed.[1]


  1. Minimal-change nephropathy and malignant thymoma. Varsano, S., Bruderman, I., Bernheim, J.L., Rathaus, M., Griffel, B. Chest (1980) [Pubmed]
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