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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome.

A methadone maintenance patient with a decreased plasma methadone level, possibly due to phenobarbital-induced acceleration of methadone biotransformation, experienced opioid withdrawal symptoms. This finding suggests that when phenobarbital is used with methadone the plasma methadone level must be monitored.[1]

References

  1. Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome. Liu, S.J., Wang, R.I. The American journal of psychiatry. (1984) [Pubmed]
 
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