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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Autoimmunity and increased c-myb transcription.

A single recessive gene, lpr, induces an autoimmune-lymphoproliferative syndrome in several strains of mice. The lymphoid organs of lpr/ lpr mice contained cells with increased amounts of myb RNA, which codes for a protein found in the nucleus. A similar human lymphoproliferative disorder also had an increase in c-myb expression. Mouse T cells induced by mitogens to proliferate did not express large amounts of myb RNA, indicating that marked myb expression is not a general feature of lymphocyte activation and proliferation.[1]


  1. Autoimmunity and increased c-myb transcription. Mountz, J.D., Steinberg, A.D., Klinman, D.M., Smith, H.R., Mushinski, J.F. Science (1984) [Pubmed]
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