Gene Review:
Myb - myeloblastosis oncogene
Mus musculus
Synonyms:
AI550390, M16449, Proto-oncogene c-Myb, Transcriptional activator Myb, c-myb
- A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Kasper, L.H., Boussouar, F., Ney, P.A., Jackson, C.W., Rehg, J., van Deursen, J.M., Brindle, P.K. Nature (2002)
- Differential regulation of c-Myb-induced transcription activation by a phosphorylation site in the negative regulatory domain. Miglarese, M.R., Richardson, A.F., Aziz, N., Bender, T.P. J. Biol. Chem. (1996)
- A Myb dependent pathway maintains Friend murine erythroleukemia cells in an immature and proliferating state. Chen, J., Kremer, C.S., Bender, T.P. Oncogene (2002)
- Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis. Schmidt, M., Nazarov, V., Stevens, L., Watson, R., Wolff, L. Mol. Cell. Biol. (2000)
- Cooperation of Myb and Myc proteins in T cell lymphomagenesis. Davies, J., Badiani, P., Weston, K. Oncogene (1999)
- A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Mucenski, M.L., McLain, K., Kier, A.B., Swerdlow, S.H., Schreiner, C.M., Miller, T.A., Pietryga, D.W., Scott, W.J., Potter, S.S. Cell (1991)
- Protooncogene expression in normal, preleukemic, and leukemic murine erythroid cells and its relationship to differentiation and proliferation. Robert-Lézénès, J., Meneceur, P., Ray, D., Moreau-Gachelin, F. Cancer Res. (1988)
- Calcium ionophore-induced transient down-regulation of c-myb mRNA levels in Friend erythroleukemia cells. Schaefer, A., Stöcker, U., Marquardt, H. J. Biol. Chem. (1993)
- c-myb effects on kinetic events during MEL cell differentiation. Danish, R., el-Awar, O., Weber, B.L., Langmore, J., Turka, L.A., Ryan, J.J., Clarke, M.F. Oncogene (1992)
- Modulation of the c-myb, c-myc and p53 mRNA and protein levels during induced murine erythroleukemia cell differentiation. Richon, V.M., Ramsay, R.G., Rifkind, R.A., Marks, P.A. Oncogene (1989)
- Nitric oxide-releasing agents and cGMP analogues inhibit murine erythroleukemia cell differentiation and suppress erythroid-specific gene expression: correlation with decreased DNA binding of NF-E2 and altered c-myb mRNA expression. Suhasini, M., Boss, G.R., Pascual, F.E., Pilz, R.B. Cell Growth Differ. (1995)
- Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Kanei-Ishii, C., Ninomiya-Tsuji, J., Tanikawa, J., Nomura, T., Ishitani, T., Kishida, S., Kokura, K., Kurahashi, T., Ichikawa-Iwata, E., Kim, Y., Matsumoto, K., Ishii, S. Genes Dev. (2004)
- c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of Tcells and is required for PKB-mediated protection from apoptosis. Lauder, A., Castellanos, A., Weston, K. Mol. Cell. Biol. (2001)
- Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb. Carabana, J., Ortigoza, E., Krangel, M.S. J. Immunol. (2005)
- c-Myc is essential but not sufficient for c-Myb-mediated block of granulocytic differentiation. Kumar, A., Lee, C.M., Reddy, E.P. J. Biol. Chem. (2003)
- Mml1, a new common integration site in murine leukemia virus-induced promonocytic leukemias maps to mouse chromosome 10. Koller, R., Krall, M., Mock, B., Bies, J., Nazarov, V., Wolff, L. Virology (1996)
- Sequential expression of proto-oncogenes during a mouse erythroleukemia cell differentiation. Todokoro, K., Ikawa, Y. Biochem. Biophys. Res. Commun. (1986)
- The C-terminal domain of B-Myb acts as a positive regulator of transcription and modulates its biological functions. Oh, I.H., Reddy, E.P. Mol. Cell. Biol. (1998)
- Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2. Hogg, A., Schirm, S., Nakagoshi, H., Bartley, P., Ishii, S., Bishop, J.M., Gonda, T.J. Oncogene (1997)
- Conditional inhibition of erythroid differentiation by c-Myb/oestrogen receptor fusion proteins. Lyon, J.J., Watson, R.J. Differentiation (1995)
- Changes in gene expression associated with induced differentiation of erythroleukemia: protooncogenes, globin genes, and cell division. Ramsay, R.G., Ikeda, K., Rifkind, R.A., Marks, P.A. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb. Kumar, A., Baker, S.J., Lee, C.M., Reddy, E.P. Mol. Cell. Biol. (2003)
- Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski. Nomura, T., Tanikawa, J., Akimaru, H., Kanei-Ishii, C., Ichikawa-Iwata, E., Khan, M.M., Ito, H., Ishii, S. J. Biol. Chem. (2004)
- Granulocytic differentiation of normal hematopoietic precursor cells induced by transcription factor PU.1 correlates with negative regulation of the c-myb promoter. Bellon, T., Perrotti, D., Calabretta, B. Blood (1997)
- Resistance to apoptosis in CTLL-2 cells overexpressing B-Myb is associated with B-Myb-dependent bcl-2 induction. Grassilli, E., Salomoni, P., Perrotti, D., Franceschi, C., Calabretta, B. Cancer Res. (1999)
- The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer. Hsiang, Y.H., Goldman, J.P., Raulet, D.H. J. Immunol. (1995)
- Myb binding sites within the N-ras promoter repress transcription. Ganter, B., Lipsick, J.S. Oncogene (1997)
- Deregulated c-myb disrupts interleukin-6- or leukemia inhibitory factor-induced myeloid differentiation prior to c-myc: role in leukemogenesis. Selvakumaran, M., Liebermann, D.A., Hoffman-Liebermann, B. Mol. Cell. Biol. (1992)
- Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. Afroze, T., Yang, L.L., Wang, C., Gros, R., Kalair, W., Hoque, A.N., Mungrue, I.N., Zhu, Z., Husain, M. Am. J. Physiol., Cell Physiol. (2003)
- Inhibition by interleukin 4 of leukemia inhibitory factor-, interleukin 6-, and dexamethasone-induced differentiation of mouse myeloid leukemia cells: role of c-myc and junB proto-oncogenes. Kasukabe, T., Okabe-Kado, J., Hozumi, M., Honma, Y. Cancer Res. (1994)
- Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes. Sakaguchi, A.Y., Lalley, P.A., Zabel, B.U., Ellis, R.W., Scolnick, E.M., Naylor, S.L. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Members of the nuclear factor kappa B family transactivate the murine c-myb gene. Toth, C.R., Hostutler, R.F., Baldwin, A.S., Bender, T.P. J. Biol. Chem. (1995)
- c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. Maurice, D., Hooper, J., Lang, G., Weston, K. EMBO J. (2007)
- Myb and ets proteins are candidate regulators of c-kit expression in human hematopoietic cells. Ratajczak, M.Z., Perrotti, D., Melotti, P., Powzaniuk, M., Calabretta, B., Onodera, K., Kregenow, D.A., Machalinski, B., Gewirtz, A.M. Blood (1998)
- Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb. Tavner, F.J., Simpson, R., Tashiro, S., Favier, D., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Macmillan, E.M., Lutwyche, J., Keough, R.A., Ishii, S., Gonda, T.J. Mol. Cell. Biol. (1998)
- Functional analysis of the c-myb proto-oncogene. Lin, H.H., Sternfeld, D.C., Shinpock, S.G., Popp, R.A., Mucenski, M.L. Curr. Top. Microbiol. Immunol. (1996)
- Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. Tahirov, T.H., Sato, K., Ichikawa-Iwata, E., Sasaki, M., Inoue-Bungo, T., Shiina, M., Kimura, K., Takata, S., Fujikawa, A., Morii, H., Kumasaka, T., Yamamoto, M., Ishii, S., Ogata, K. Cell (2002)
- Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Metcalf, D., Carpinelli, M.R., Hyland, C., Mifsud, S., Dirago, L., Nicola, N.A., Hilton, D.J., Alexander, W.S. Blood (2005)