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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A clinical and ultrastructural study of osteogenesis imperfecta after flavonoid (Catergen) therapy.

A trial of the flavonoid Catergen (Zyma) has been undertaken in 11 adults with osteogenesis imperfecta (Ol). The only significant clinical or metabolic side-effects were severe headaches, which necessitated the withdrawal of 3 patients from the trial. Patient compliance in terms of palatability of Catergen was good, and 3 of the 8 patients who completed the trial experienced subjective improvement. After 6 months' treatment with Catergen, the abnormally narrow collagen fibrils found in the osteoid region in a pretreatment bone biopsy specimen from a middle-aged man with the common type 1 (autosomal dominant) form of Ol showed a significant reversion to normal diameters. Post-treatment specimens from his 2 affected sons, who exhibited the same defect, showed a similar but less marked response.[1]


  1. A clinical and ultrastructural study of osteogenesis imperfecta after flavonoid (Catergen) therapy. Jones, C.J., Cummings, C., Ball, J., Beighton, P. S. Afr. Med. J. (1984) [Pubmed]
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