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MeSH Review

Middle Aged

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Disease relevance of Middle Aged


Psychiatry related information on Middle Aged


High impact information on Middle Aged

  • CONCLUSIONS: The fortification of enriched grain products with folic acid was associated with a substantial improvement in folate status in a population of middle-aged and older adults [11].
  • The increased risk of cardiovascular disease associated with higher serum cholesterol levels in middle-aged persons has been clearly established, but there have been few opportunities to examine a potential link between serum cholesterol levels measured in young men and clinically evident premature cardiovascular disease later in life [12].
  • The antigenic molecule can be extracted from senescent but not young RBCs with Triton X-100 (ref. 4), although 10--30% as much antigen can be extracted from middle-aged as from senescent RBCs [13].
  • OBJECTIVE: To determine whether elevated levels of the inflammatory markers interleukin 6 (IL-6) and C-reactive protein (CRP) are associated with development of type 2 DM in healthy middle-aged women [14].
  • Further analysis showed that only middle-aged men with very high levels of anxiety were at increased risk (relative risk, 2.19; 95% confidence interval, 1.22 to 3.94) [15].

Chemical compound and disease context of Middle Aged


Biological context of Middle Aged


Anatomical context of Middle Aged


Associations of Middle Aged with chemical compounds


Gene context of Middle Aged


Analytical, diagnostic and therapeutic context of Middle Aged

  • The effect of breathing 100 ppm of carbon monoxide versus compressed, purified air for 1 h on maximal treadmill exericse was studied (double-blind crossover design) in 10 middle-aged, healthy nonsmokers [39].
  • CONCLUSION: Priming of AML cells to the cytotoxic effects of CT by the use of GM-CSF during CT or accelerating myeloid recovery by the use of GM-CSF after CT does not significantly improve treatment outcome of young and middle-aged adults with newly diagnosed AML [40].
  • Glucose tolerant middle-aged subjects homozygous for the polymorphism (n = 31), however, had on average a 25 % decrease in fasting serum insulin concentrations (p = 0.009) and 28 % (p = 0.01) and 34 % (p = 0.003) reductions in serum insulin concentrations at 30 and 60 min, respectively, during an OGTT compared with wildtype carriers (n = 107) [41].
  • We randomly assigned 522 (172 men, 350 women) middle-aged (mean age 55 yr), overweight (mean body mass index 31 kg/m(2)) subjects with impaired glucose tolerance either to the lifestyle intervention or control group [42].
  • RESEARCH DESIGN AND METHODS: We conducted a prospective cohort study of 1,152 white male medical students in The Johns Hopkins Precursors Study to longitudinally assess systolic BP (SBP) and diastolic BP (DBP) from young adulthood through middle age in men who went on to develop diabetes [43].


  1. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Hanis, C.L., Boerwinkle, E., Chakraborty, R., Ellsworth, D.L., Concannon, P., Stirling, B., Morrison, V.A., Wapelhorst, B., Spielman, R.S., Gogolin-Ewens, K.J., Shepard, J.M., Williams, S.R., Risch, N., Hinds, D., Iwasaki, N., Ogata, M., Omori, Y., Petzold, C., Rietzch, H., Schröder, H.E., Schulze, J., Cox, N.J., Menzel, S., Boriraj, V.V., Chen, X., Lim, L.R., Lindner, T., Mereu, L.E., Wang, Y.Q., Xiang, K., Yamagata, K., Yang, Y., Bell, G.I. Nat. Genet. (1996) [Pubmed]
  2. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. Tuomilehto, J., Lindström, J., Eriksson, J.G., Valle, T.T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., Salminen, V., Uusitupa, M. N. Engl. J. Med. (2001) [Pubmed]
  3. Down's syndrome in adults: brain metabolism. Schwartz, M., Duara, R., Haxby, J., Grady, C., White, B.J., Kessler, R.M., Kay, A.D., Cutler, N.R., Rapoport, S.I. Science (1983) [Pubmed]
  4. Combined estrogen and progestin hormone replacement therapy in relation to risk of breast cancer in middle-aged women. Stanford, J.L., Weiss, N.S., Voigt, L.F., Daling, J.R., Habel, L.A., Rossing, M.A. JAMA (1995) [Pubmed]
  5. beta-blockers or diuretics in hypertension? A six year follow-up of blood pressure and metabolic side effects. Berglund, G., Andersson, O. Lancet (1981) [Pubmed]
  6. Chemical pathology of Huntington's disease. Bird, E.D. Annu. Rev. Pharmacol. Toxicol. (1980) [Pubmed]
  7. Pemoline abuse. Polchert, S.E., Morse, R.M. JAMA (1985) [Pubmed]
  8. Alcohol use and mortality from coronary heart disease: the role of high-density lipoprotein cholesterol. The Multiple Risk Factor Intervention Trial Research Group. Suh, I., Shaten, B.J., Cutler, J.A., Kuller, L.H. Ann. Intern. Med. (1992) [Pubmed]
  9. Daily physical activity, work capacity and glucose tolerance in lean and obese normoglycaemic middle-aged men. Lindgärde, F., Saltin, B. Diabetologia (1981) [Pubmed]
  10. Depressive symptoms and lack of social integration in relation to prognosis of CHD in middle-aged women. The Stockholm Female Coronary Risk Study. Horsten, M., Mittleman, M.A., Wamala, S.P., Schenck-Gustafsson, K., Orth-Gomér, K. Eur. Heart J. (2000) [Pubmed]
  11. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. Jacques, P.F., Selhub, J., Bostom, A.G., Wilson, P.W., Rosenberg, I.H. N. Engl. J. Med. (1999) [Pubmed]
  12. Serum cholesterol in young men and subsequent cardiovascular disease. Klag, M.J., Ford, D.E., Mead, L.A., He, J., Whelton, P.K., Liang, K.Y., Levine, D.M. N. Engl. J. Med. (1993) [Pubmed]
  13. Isolation of the phagocytosis-inducing IgG-binding antigen on senescent somatic cells. Kay, M.M. Nature (1981) [Pubmed]
  14. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. Pradhan, A.D., Manson, J.E., Rifai, N., Buring, J.E., Ridker, P.M. JAMA (2001) [Pubmed]
  15. Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension? Markovitz, J.H., Matthews, K.A., Kannel, W.B., Cobb, J.L., D'Agostino, R.B. JAMA (1993) [Pubmed]
  16. Dietary cholesterol and ischaemic heart disease. Shekelle, R.B., Stamler, J. Lancet (1989) [Pubmed]
  17. Dietary vitamin A and risk of cancer in the Western Electric study. Shekelle, R.B., Lepper, M., Liu, S., Maliza, C., Raynor, W.J., Rossof, A.H., Paul, O., Shryock, A.M., Stamler, J. Lancet (1981) [Pubmed]
  18. Randomised trial of 23-valent pneumococcal capsular polysaccharide vaccine in prevention of pneumonia in middle-aged and elderly people. Swedish Pneumococcal Vaccination Study Group. Ortqvist, A., Hedlund, J., Burman, L.A., Elbel, E., Höfer, M., Leinonen, M., Lindblad, I., Sundelöf, B., Kalin, M. Lancet (1998) [Pubmed]
  19. Severe hepatocellular reaction resembling alcoholic hepatitis with cirrhosis after massive small bowel resection and prolonged total parenteral nutrition. Craig, R.M., Neumann, T., Jeejeebhoy, K.N., Yokoo, H. Gastroenterology (1980) [Pubmed]
  20. Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography. Herrington, D.M., Gordon, G.B., Achuff, S.C., Trejo, J.F., Weisman, H.F., Kwiterovich, P.O., Pearson, T.A. J. Am. Coll. Cardiol. (1990) [Pubmed]
  21. Caliban's heritance and the genetics of neuronal aging. Teter, B., Finch, C.E. Trends Neurosci. (2004) [Pubmed]
  22. Prediction of coronary heart disease using risk factor categories. Wilson, P.W., D'Agostino, R.B., Levy, D., Belanger, A.M., Silbershatz, H., Kannel, W.B. Circulation (1998) [Pubmed]
  23. Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma. Adam, M.F., Belmouden, A., Binisti, P., Brézin, A.P., Valtot, F., Béchetoille, A., Dascotte, J.C., Copin, B., Gomez, L., Chaventré, A., Bach, J.F., Garchon, H.J. Hum. Mol. Genet. (1997) [Pubmed]
  24. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Alpdogan, O., Schmaltz, C., Muriglan, S.J., Kappel, B.J., Perales, M.A., Rotolo, J.A., Halm, J.A., Rich, B.E., van den Brink, M.R. Blood (2001) [Pubmed]
  25. IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. Al-Zahrani, A., Sandhu, M.S., Luben, R.N., Thompson, D., Baynes, C., Pooley, K.A., Luccarini, C., Munday, H., Perkins, B., Smith, P., Pharoah, P.D., Wareham, N.J., Easton, D.F., Ponder, B.A., Dunning, A.M. Hum. Mol. Genet. (2006) [Pubmed]
  26. Interaction of rapid signal transduction cascades and gene expression in mediating estrogen effects on memory over the life span. Foster, T.C. Frontiers in neuroendocrinology. (2005) [Pubmed]
  27. Coronary artery size and dilating capacity in ultradistance runners. Haskell, W.L., Sims, C., Myll, J., Bortz, W.M., St Goar, F.G., Alderman, E.L. Circulation (1993) [Pubmed]
  28. Alteration in membrane protein band 3 associated with accelerated erythrocyte aging. Kay, M.M., Flowers, N., Goodman, J., Bosman, G. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  29. Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Alpdogan, O., Hubbard, V.M., Smith, O.M., Patel, N., Lu, S., Goldberg, G.L., Gray, D.H., Feinman, J., Kochman, A.A., Eng, J.M., Suh, D., Muriglan, S.J., Boyd, R.L., van den Brink, M.R. Blood (2006) [Pubmed]
  30. Relation of diet to high-density-lipoprotein cholesterol in middle-aged marathon runners, joggers, and inactive men. Hartung, G.H., Foreyt, J.P., Mitchell, R.E., Vlasek, I., Gotto, A.M. N. Engl. J. Med. (1980) [Pubmed]
  31. Pulmonary infiltrates associated with naproxen. Buscaglia, A.J., Cowden, F.E., Brill, H. JAMA (1984) [Pubmed]
  32. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Perry, I.J., Refsum, H., Morris, R.W., Ebrahim, S.B., Ueland, P.M., Shaper, A.G. Lancet (1995) [Pubmed]
  33. Cigarette smoking and risk for impaired fasting glucose and type 2 diabetes in middle-aged Japanese men. Nakanishi, N., Nakamura, K., Matsuo, Y., Suzuki, K., Tatara, K. Ann. Intern. Med. (2000) [Pubmed]
  34. Catechol O-methyltransferase Val158Met polymorphism is associated with cognitive performance in nondemented adults. de Frias, C.M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., Nilsson, L.G. Journal of cognitive neuroscience. (2005) [Pubmed]
  35. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Laaksonen, D.E., Niskanen, L., Punnonen, K., Nyyssönen, K., Tuomainen, T.P., Valkonen, V.P., Salonen, R., Salonen, J.T. Diabetes Care (2004) [Pubmed]
  36. Fine localisation of the gene for central areolar choroidal dystrophy on chromosome 17p. Hughes, A.E., Lotery, A.J., Silvestri, G. J. Med. Genet. (1998) [Pubmed]
  37. Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women: impact on cardiovascular mortality. Piemonti, L., Calori, G., Mercalli, A., Lattuada, G., Monti, P., Garancini, M.P., Costantino, F., Ruotolo, G., Luzi, L., Perseghin, G. Diabetes Care (2003) [Pubmed]
  38. Pheno/genotypic correlations of neuronal ceroid lipofuscinoses. Wisniewski, K.E., Zhong, N., Philippart, M. Neurology (2001) [Pubmed]
  39. Effect of carbon monoxide on maximal treadmill exercise. A study in normal persons. Aronow, W.S., Cassidy, J. Ann. Intern. Med. (1975) [Pubmed]
  40. Value of different modalities of granulocyte-macrophage colony-stimulating factor applied during or after induction therapy of acute myeloid leukemia. Löwenberg, B., Boogaerts, M.A., Daenen, S.M., Verhoef, G.E., Hagenbeek, A., Vellenga, E., Ossenkoppele, G.J., Huijgens, P.C., Verdonck, L.F., van der Lelie, J., Wielenga, J.J., Schouten, H.C., Gmür, J., Gratwohl, A., Hess, U., Fey, M.F., van Putten, W.L. J. Clin. Oncol. (1997) [Pubmed]
  41. Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity. Almind, K., Frederiksen, S.K., Bernal, D., Hansen, T., Ambye, L., Urhammer, S., Ekstrøm, C.T., Berglund, L., Reneland, R., Lithell, H., White, M.F., Van Obberghen, E., Pedersen, O. Diabetologia (1999) [Pubmed]
  42. Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the finnish diabetes prevention study: results from a randomized clinical trial. Lindström, J., Eriksson, J.G., Valle, T.T., Aunola, S., Cepaitis, Z., Hakumäki, M., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Mannelin, M., Martikkala, V., Moltchanov, V., Rastas, M., Salminen, V., Sundvall, J., Uusitupa, M., Tuomilehto, J. J. Am. Soc. Nephrol. (2003) [Pubmed]
  43. Blood pressure in young adulthood and the risk of type 2 diabetes in middle age. Golden, S.H., Wang, N.Y., Klag, M.J., Meoni, L.A., Brancati, F.L. Diabetes Care (2003) [Pubmed]
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