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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Heterogeneity of Es-1 esterases in the rabbit (Oryctolagus cuniculus).

Analysis of the Es-1 system in the rabbit with polyacrylamide gel electrophoresis (PAGE) revealed a high degree of individual variation. In the liver the number of esterase bands found in the Es-1 region of the gels ranged from 2 to 16. The results indicate that one locus with three alleles is responsible for all of the esterase bands in the Es-1 region. The most plausible explanation for the observed heterogeneity is that each of the alleles codes for a protein (MW 65,000 +/- 2000) that is changed by posttranslational modifications, thus giving rise to two to five monomeric enzymes with esterase activity. Polymerization of these monomers then results in 1-11 dimers. Based on similarities with mouse Es-9, chromosomal homology between rabbit Es-1 and mouse Es-9 is proposed.[1]


  1. Heterogeneity of Es-1 esterases in the rabbit (Oryctolagus cuniculus). Bellen, H., Van de Weghe, A., Bouquet, Y., Van Zutphen, L.F. Biochem. Genet. (1984) [Pubmed]
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