The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Studies on fertility control-the formation and antifertility effect of polyvinyl-pyrolidone-gossypol complex.

In this study, PVP-gossypol complexes with different molecular weights and compositions were synthesized. UV and NMR spectra revealed the presence of hydrogen bonds in these complexes. The dissolution rates of various PVP-gossypol complexes in water at 37 degrees C were determined. The results showed that the presence of PVP in the complex enhanced the dissolution rate of gossypol in water greatly. In addition, the in vitro spermicidal activity on human semen, antifertility effect on male rats, and the toxic reaction of male mice by taking large dosage were preliminarily studied. The experimental results indicated that the PVP-gossypol complexes not only possessed the similar antifertility effect and acute toxicity to male mice as gossypol-acetic acid, but also reduced the irreversibility of the fertility as well. Thus, certain species of PVP-gossypol complex may have potential as new and better male oral contraceptive with recoverability in fertility.[1]

References

  1. Studies on fertility control-the formation and antifertility effect of polyvinyl-pyrolidone-gossypol complex. Gu, Z.W., Jiang, Y., Feng, X.D. Biomaterials, medical devices, and artificial organs. (1984) [Pubmed]
 
WikiGenes - Universities