Chemical Compound Review:
gossypol 2,3,8-trihydroxy-6-methyl-4- propan-2-yl-7...
Synonyms:
Pogosin, UPCMLD-DP103, No Fertil, Tash 1, Prestwick_1031, ...
- Lactic dehydrogenase isozymes, 31P magnetic resonance spectroscopy, and in vitro antimitochondrial tumor toxicity with gossypol and rhodamine-123. Benz, C., Hollander, C., Keniry, M., James, T.L., Mitchell, M. J. Clin. Invest. (1987)
- Cytogenetic analysis of a gossypol-induced murine myxosarcoma. Dhaliwal, M.K., Norman, J.O., Pathak, S., Busbee, D.L. J. Natl. Cancer Inst. (1987)
- An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma. Wu, Y.W., Chik, C.L., Knazek, R.A. Cancer Res. (1989)
- Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines. Tuszynski, G.P., Cossu, G. Cancer Res. (1984)
- Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Jarvis, W.D., Turner, A.J., Povirk, L.F., Traylor, R.S., Grant, S. Cancer Res. (1994)
- Action of gossypol and rhodamine 123 on wild type and multidrug-resistant MCF-7 human breast cancer cells: 31P nuclear magnetic resonance and toxicity studies. Jaroszewski, J.W., Kaplan, O., Cohen, J.S. Cancer Res. (1990)
- Prolactin-dependent mitogenesis in Nb 2 node lymphoma cells: effects of immunosuppressive cyclopeptides. Russell, D.H., Buckley, A.R., Montgomery, D.W., Larson, N.A., Gout, P.W., Beer, C.T., Putnam, C.W., Zukoski, C.F., Kibler, R. J. Immunol. (1987)
- Gossypol: prototype of inhibitors targeted to dinucleotide folds. Vander Jagt, D.L., Deck, L.M., Royer, R.E. Current medicinal chemistry. (2000)
- Effect of gossypol on the thyroid in young rats. Rikihisa, Y., Lin, Y.C. J. Comp. Pathol. (1989)
- Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. Gilbert, N.E., O'Reilly, J.E., Chang, C.J., Lin, Y.C., Brueggemeier, R.W. Life Sci. (1995)
- The effect of the association of Gossypol and Lonidamine on the energy metabolism of Ehrlich ascites tumor cells. Floridi, A., D'Atri, S., Menichini, R., Marcante, M.L., Nista, A., Silvestrini, B., Caputo, A., De Martino, C. Exp. Mol. Pathol. (1983)
- Effect of gossypol on DNA synthesis and cell cycle progression of mammalian cells in vitro. Wang, Y., Rao, P.N. Cancer Res. (1984)
- Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol. Baumgrass, R., Weiwad, M., Erdmann, F., Liu, J.O., Wunderlich, D., Grabley, S., Fischer, G. J. Biol. Chem. (2001)
- Gossypol induces DNA strand breaks in human fibroblasts and sister chromatid exchanges in human lymphocytes in vitro. Nordenskjöld, M., Lambert, B. J. Med. Genet. (1984)
- Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates. Yu, B.Z., Rogers, J., Ranadive, G., Baker, S., Wilton, D.C., Apitz-Castro, R., Jain, M.K. Biochemistry (1997)
- S-100 modulates Ca2+-independent phosphorylation of an endogenous protein (Mr = 19K) in brain. Qi, D.F., Kuo, J.F. J. Neurochem. (1984)
- Gossypol, a hyperthermic sensitizer of HeLa cells. Kim, S.H., Kim, J.H., Alfieri, A.A., He, S.Q., Young, C.W. Cancer Res. (1985)
- Modulation of 4'-(9-acridinylamino)methanesulfon-m-anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol. Adlakha, R.C., Ashorn, C.L., Chan, D., Zwelling, L.A. Cancer Res. (1989)
- The potential of antispermatogenic drugs against trypanosomatids. Turrens, J.F. Parasitol. Today (Regul. Ed.) (1986)
- Endothelium-derived relaxing factor (EDRF): a defence mechanism against platelet aggregation and vasospasm in human coronary arteries. Förstermann, U., Mügge, A., Alheid, U., Bode, S.M., Frölich, J.C. Eur. Heart J. (1989)
- Antisense suppression of a (+)-delta-cadinene synthase gene in cotton prevents the induction of this defense response gene during bacterial blight infection but not its constitutive expression. Townsend, B.J., Poole, A., Blake, C.J., Llewellyn, D.J. Plant Physiol. (2005)
- Metabolism of round spermatids: gossypol induces uncoupling of respiratory chain and oxidative phosphorylation. Nakamura, M., Ikeda, M., Suzuki, A., Okinaga, S., Arai, K. Biol. Reprod. (1988)
- Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Kitada, S., Kress, C.L., Krajewska, M., Jia, L., Pellecchia, M., Reed, J.C. Blood (2008)
- Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line. Chang, J.S., Hsu, Y.L., Kuo, P.L., Chiang, L.C., Lin, C.C. Clin. Exp. Pharmacol. Physiol. (2004)
- Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. Lei, X., Chen, Y., Du, G., Yu, W., Wang, X., Qu, H., Xia, B., He, H., Mao, J., Zong, W., Liao, X., Mehrpour, M., Hao, X., Chen, Q. FASEB J. (2006)
- Effects of gossypol on the antioxidant defense system of the rat testis. Bender, H.S., Derolf, S.Z., Misra, H.P. Arch. Androl. (1988)
- Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells. Ligueros, M., Jeoung, D., Tang, B., Hochhauser, D., Reidenberg, M.M., Sonenberg, M. Br. J. Cancer (1997)
- Blockade of swelling-induced chloride channels by phenol derivatives. Gschwentner, M., Jungwirth, A., Hofer, S., Wöll, E., Ritter, M., Susanna, A., Schmarda, A., Reibnegger, G., Pinggera, G.M., Leitinger, M., Frick, J., Deetjen, P., Paulmichl, M. Br. J. Pharmacol. (1996)
- Molecular cloning and functional identification of (+)-delta-cadinene-8-hydroxylase, a cytochrome P450 mono-oxygenase (CYP706B1) of cotton sesquiterpene biosynthesis. Luo, P., Wang, Y.H., Wang, G.D., Essenberg, M., Chen, X.Y. Plant J. (2001)
- Synthesis and anti-HIV activity of 1,1'-dideoxygossypol and related compounds. Royer, R.E., Deck, L.M., Vander Jagt, T.J., Martinez, F.J., Mills, R.G., Young, S.A., Vander Jagt, D.L. J. Med. Chem. (1995)
- Segmental aplasia of the mitochondrial sheath and sequelae induced by gossypol in rat spermatozoa. Oko, R., Hrudka, F. Biol. Reprod. (1982)