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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes.

The effect of several pineal methoxyindoles on 45Ca2+-uptake was examined in a crude synaptosome preparation from adult rat brains. 5-Methoxytryptol, 5-methoxytryptamine, melatonin and 6-chloromelatonin (10(-8)-10(-6) M) depressed significantly the K+-stimulated increase in Ca2+-uptake, without affecting the basal, unstimulated Ca2+-uptake by synaptosomes. At 10(-6) M concentration the following order of potency was found: 6-chloromelatonin greater than or equal to 5-methoxytryptamine greater than 5-methoxytryptophol greater than or equal to melatonin. Serotonin did not affect significantly either basal or stimulated Ca2+-uptake.[1]

References

  1. Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes. Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P. Brain Res. (1984) [Pubmed]
 
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