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Chemical Compound Review

Lopac-C-0331     N-[2-(6-chloro-5-methoxy-1H- indol-3...

Synonyms: Tocris-0443, CHEMBL34730, SureCN677517, SureCN677518, AG-J-38755, ...
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Disease relevance of BRN 0410191

  • This effect of 6-chloromelatonin on forskolin-stimulated HCG-beta secretion was abolished by pertussis toxin (PTX), suggesting that melatonin regulates hCG-beta production by an action involving an inhibitory Gi/o protein [1].

High impact information on BRN 0410191


Biological context of BRN 0410191


Anatomical context of BRN 0410191


Associations of BRN 0410191 with other chemical compounds


Gene context of BRN 0410191

  • Melatonin, 6-chloromelatonin, 2,3-dihydromelatonin and 6-chloro-2,3-dihydromelatonin decreased plasma prolactin to 31, 45, 54 and 48% of control levels respectively when administered daily (100 micrograms at 1600 h) for 21 days [13].

Analytical, diagnostic and therapeutic context of BRN 0410191


  1. Expression of melatoninergic receptors in human placental choriocarcinoma cell lines. Lanoix, D., Ouellette, R., Vaillancourt, C. Hum. Reprod. (2006) [Pubmed]
  2. 2-[125I]iodomelatonin-binding sites in the human kidney and the effect of guanosine 5'-O-(3-thiotriphosphate). Song, Y., Tam, P.C., Poon, A.M., Brown, G.M., Pang, S.F. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  3. The modulation of neuronal activity by melatonin: in vitro studies on mouse hippocampal slices. Hogan, M.V., El-Sherif, Y., Wieraszko, A. J. Pineal Res. (2001) [Pubmed]
  4. Photophysical studies on melatonin and its receptor agonists. Roberts, J.E., Hu, D.N., Martinez, L., Chignell, C.F. J. Pineal Res. (2000) [Pubmed]
  5. Melatonin receptor-mediated stimulation of phosphoinositide breakdown in chick brain slices. Popova, J.S., Dubocovich, M.L. J. Neurochem. (1995) [Pubmed]
  6. Activation of melatonin receptor sites retarded the depletion of norepinephrine following inhibition of synthesis in the C3H/HeN mouse hypothalamus. Fang, J.M., Dubocovich, M.L. J. Neurochem. (1990) [Pubmed]
  7. Luzindole (N-0774): a novel melatonin receptor antagonist. Dubocovich, M.L. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  8. Inhibition of luteinizing hormone release and ovulation by 6-chloro- and 6-fluoromelatonin. Clemens, J.A., Flaugh, M.E., Parli, J., Sawyer, B.D. Neuroendocrinology (1980) [Pubmed]
  9. MT(2) melatonin receptors are present and functional in rat caudal artery. Masana, M.I., Doolen, S., Ersahin, C., Al-Ghoul, W.M., Duckles, S.P., Dubocovich, M.L., Krause, D.N. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  10. Pineal methoxyindoles depress calcium uptake by rat brain synaptosomes. Vacas, M.I., Keller Sarmiento, M.I., Cardinali, D.P. Brain Res. (1984) [Pubmed]
  11. Retinal [125I]iodomelatonin binding sites in the tree shrew (Tupaiidae). Lu, Y., Yuan, H., Pang, S.F. Neurosci. Lett. (1991) [Pubmed]
  12. Natural and synthetic analogues of melatonin and related compounds. II. Effects on plasma thyroid hormones and cholesterol levels in male Syrian hamsters. Vaughan, M.K., Richardson, B.A., Johnson, L.Y., Petterborg, L.J., Powanda, M.C., Reiter, R.J., Smith, I. J. Neural Transm. (1983) [Pubmed]
  13. Prolactin response in Border-Leicester x merino ewes to administration of melatonin, melatonin analogues, a melatonin metabolite and 6-methoxybenzoxazolinone. Kennaway, D.J., Royles, P., Dunstan, E.A., Hugel, H.M. Aust. J. Biol. Sci. (1986) [Pubmed]
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