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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Mitral valve prolapse: a review of associated arrhythmias.

The syndrome of mitral valve prolapse with associated auscultatory-electrocardiographic findings is now well documented. Two representative cases of repetitive tachyarrhythmias in patients with mitral valve prolapse are discussed as well as an analysis of the 589 cases in the English literature of arrhythmias in patients with mitral valve prolapse. The average age of the patients was 38 years; 70 per cent of them were women. Symptoms were variable, but palpitations occurred in 44 per cent, lightheadedness in 12 per cent and syncope in 4 per cent. Premature atrial and/or ventricular contractions were found in 55 per cent, premature ventricular contractions in 45 per cent, supraventricular tachycardia in 6.1 per cent and ventricular tachycardia in 6.3 per cent. Sudden death was noted in 1.4 per cent. A discussion of the pathogenesis of arrhythmias and therapy concludes this review.[1]


  1. Mitral valve prolapse: a review of associated arrhythmias. Swartz, M.H., Teichholz, L.E., Donoso, E. Am. J. Med. (1977) [Pubmed]
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