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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Biochemical characterization of 17 beta-hydroxysteroid dehydrogenase in human meningioma.

17 beta-Hydroxysteroid dehydrogenase (E2-DH) activity was characterized on a semipurified microsomal preparation of human meningioma tissue (mean Km of 2 microM and Vmax of 500 pmol/mg protein/10 min) and then assayed in 49 meningioma specimens with high progesterone receptor and low estrogen receptor levels. Of these 49 tumors, 36% contained an E2-DH activity greater than 1,000 pmol/mg protein/10 min and similar to that of uterine myometrium. In this limited series of tumors, no correlation between E2-DH activity and progesterone receptor levels was noted.[1]


  1. Biochemical characterization of 17 beta-hydroxysteroid dehydrogenase in human meningioma. Martin, P.M., Rieg, A.M., Fournier, S., Magdelenat, H., Hassoun, J., Pertuiset, B., Poisson, M., Vigouroux, R.P., Toga, M. Clinical neuropharmacology. (1984) [Pubmed]
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