Gene Review:
PGR - progesterone receptor
Homo sapiens
Synonyms:
NR3C3, Nuclear receptor subfamily 3 group C member 3, PR, Progesterone receptor
Enger,
Ross,
Paganini-Hill,
Carpenter,
Bernstein,
Schneider,
Pollán,
Tejerina,
Sánchez,
Lucas,
Ma,
Bernstein,
Ross,
Ursin,
Tecimer,
Doering,
Goldsmith,
Meyer,
Abdulhay,
Wittliff,
Gold,
Kalush,
Bergeron,
Scott,
Mitra,
Wilson,
Ellis,
Huang,
Chen,
Lippert,
Halldorsson,
Woodworth,
White,
Clark,
Parl,
Broder,
Dean,
Offit,
Latil,
Bièche,
Vidaud,
Lidereau,
Berthon,
Cussenot,
Vidaud,
El-Shalakany,
Kamel,
Ismail,
Salah,
El-Deen Fahmy,
El-Deen Ammar,
Murphy,
Niu,
Snell,
Watson,
- Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Gold, B., Kalush, F., Bergeron, J., Scott, K., Mitra, N., Wilson, K., Ellis, N., Huang, H., Chen, M., Lippert, R., Halldorsson, B.V., Woodworth, B., White, T., Clark, A.G., Parl, F.F., Broder, S., Dean, M., Offit, K. Cancer Res. (2004)
- Androgen receptor expression in male breast carcinoma: lack of clinicopathological association. Pich, A., Margaria, E., Chiusa, L., Candelaresi, G., Dal Canton, O. Br. J. Cancer (1999)
- Clinicopathological features and molecular markers of breast cancer in Jos, Nigeria. Gukas, I.D., Jennings, B.A., Mandong, B.M., Igun, G.O., Girling, A.C., Manasseh, A.N., Ugwu, B.T., Leinster, S.J. West African journal of medicine. (2005)
- Estrogen and progesterone receptors and telomerase enzyme immunohistochemical detection in gestational trophoblastic tumors. El-Shalakany, A.H., Kamel, K.M., Ismail, A.M., Salah, L., El-Deen Fahmy, S.S., El-Deen Ammar, E. Int. J. Gynecol. Cancer (2006)
- Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. Kastner, P., Krust, A., Turcotte, B., Stropp, U., Tora, L., Gronemeyer, H., Chambon, P. EMBO J. (1990)
- Hormone-related risk factors for breast cancer in women under age 50 years by estrogen and progesterone receptor status: results from a case-control and a case-case comparison. Ma, H., Bernstein, L., Ross, R.K., Ursin, G. Breast Cancer Res. (2006)
- Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women. Ho, H.P., Westberg, L., Annerbrink, K., Olsson, M., Melke, J., Nilsson, S., Baghaei, F., Rosmond, R., Holm, G., Björntorp, P., Andersch, S., Allgulander, C., Eriksson, E. Psychoneuroendocrinology (2004)
- Body size, physical activity, and breast cancer hormone receptor status: results from two case-control studies. Enger, S.M., Ross, R.K., Paganini-Hill, A., Carpenter, C.L., Bernstein, L. Cancer Epidemiol. Biomarkers Prev. (2000)
- Hormones in breast cancer: update 1978. McGuire, W.L., Horwitz, K.B., Zava, D.T., Garola, R.E., Chamness, G.C. Metab. Clin. Exp. (1978)
- Individual differences between nuclear parameters of normal and malignant breast epithelium. Pikula, B., Savjak, D., Hacker, G.W., Muss, W.H., Amidzic, L., Hauser-Kronberger, C., Malesevic, D., Dietze, O. Zentralbl. Pathol. (1994)
- The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Vegeto, E., Allan, G.F., Schrader, W.T., Tsai, M.J., McDonnell, D.P., O'Malley, B.W. Cell (1992)
- Indicators of prognosis in node-negative breast cancer. Sigurdsson, H., Baldetorp, B., Borg, A., Dalberg, M., Fernö, M., Killander, D., Olsson, H. N. Engl. J. Med. (1990)
- The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex. Klein-Hitpass, L., Tsai, S.Y., Weigel, N.L., Allan, G.F., Riley, D., Rodriguez, R., Schrader, W.T., Tsai, M.J., O'Malley, B.W. Cell (1990)
- Steroid hormone receptors compete for factors that mediate their enhancer function. Meyer, M.E., Gronemeyer, H., Turcotte, B., Bocquel, M.T., Tasset, D., Chambon, P. Cell (1989)
- Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance. Horwitz, K.B., Mockus, M.B., Lessey, B.A. Cell (1982)
- Decrease in estradiol-stimulated progesterone receptor production in MCF-7 cells by epidermal growth factor and possible clinical implication for paracrine-regulated breast cancer growth. Cormier, E.M., Wolf, M.F., Jordan, V.C. Cancer Res. (1989)
- Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer. Johnston, S.R., Saccani-Jotti, G., Smith, I.E., Salter, J., Newby, J., Coppen, M., Ebbs, S.R., Dowsett, M. Cancer Res. (1995)
- Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo. Zhang, Y., Beck, C.A., Poletti, A., Clement, J.P., Prendergast, P., Yip, T.T., Hutchens, T.W., Edwards, D.P., Weigel, N.L. Mol. Endocrinol. (1997)
- Nonsteroidal human progesterone receptor modulators from the marine alga Cymopolia barbata. Pathirana, C., Stein, R.B., Berger, T.S., Fenical, W., Ianiro, T., Mais, D.E., Torres, A., Goldman, M.E. Mol. Pharmacol. (1995)
- Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells. Xu, Q., Takekida, S., Ohara, N., Chen, W., Sitruk-Ware, R., Johansson, E.D., Maruo, T. J. Clin. Endocrinol. Metab. (2005)
- Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer. Konecny, G., Pauletti, G., Pegram, M., Untch, M., Dandekar, S., Aguilar, Z., Wilson, C., Rong, H.M., Bauerfeind, I., Felber, M., Wang, H.J., Beryt, M., Seshadri, R., Hepp, H., Slamon, D.J. J. Natl. Cancer Inst. (2003)
- Steroid receptor induction of gene transcription: a two-step model. Jenster, G., Spencer, T.E., Burcin, M.M., Tsai, S.Y., Tsai, M.J., O'Malley, B.W. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Jones, M.C., Fusi, L., Higham, J.H., Abdel-Hafiz, H., Horwitz, K.B., Lam, E.W., Brosens, J.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Cellular distribution of retinoic acid receptor-alpha in benign hyperplastic and malignant human prostates: comparison with androgen, estrogen and progesterone receptor status. Gyftopoulos, K., Sotiropoulou, G., Varakis, I., Barbalias, G.A. Eur. Urol. (2000)
- Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United States. Elledge, R.M., Clark, G.M., Chamness, G.C., Osborne, C.K. J. Natl. Cancer Inst. (1994)
- Modulation of AP-1 activity by the human progesterone receptor in endometrial adenocarcinoma cells. Bamberger, A.M., Bamberger, C.M., Gellersen, B., Schulte, H.M. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells. Lau, K.M., Mok, S.C., Ho, S.M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486. Liu, Z., Auboeuf, D., Wong, J., Chen, J.D., Tsai, S.Y., Tsai, M.J., O'Malley, B.W. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Evaluation of androgen, estrogen (ER alpha and ER beta), and progesterone receptor expression in human prostate cancer by real-time quantitative reverse transcription-polymerase chain reaction assays. Latil, A., Bièche, I., Vidaud, D., Lidereau, R., Berthon, P., Cussenot, O., Vidaud, M. Cancer Res. (2001)
- Urokinase-type plasminogen activator and its inhibitor PAI-1: predictors of poor response to tamoxifen therapy in recurrent breast cancer. Foekens, J.A., Look, M.P., Peters, H.A., van Putten, W.L., Portengen, H., Klijn, J.G. J. Natl. Cancer Inst. (1995)
- Effect of P-glycoprotein expression on sensitivity to hormones in MCF-7 human breast cancer cells. Clarke, R., Currier, S., Kaplan, O., Lovelace, E., Boulay, V., Gottesman, M.M., Dickson, R.B. J. Natl. Cancer Inst. (1992)
- Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. Liu, Z., Wong, J., Tsai, S.Y., Tsai, M.J., O'Malley, B.W. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Demethylation of the progesterone receptor CpG island is not required for progesterone receptor gene expression. Ferguson, A.T., Lapidus, R.G., Davidson, N.E. Oncogene (1998)
- Accumulation of uPA-PAI-1 complexes inside the tumour cells is associated with axillary nodal invasion in progesterone-receptor-positive early breast cancer. Schneider, J., Pollán, M., Tejerina, A., Sánchez, J., Lucas, A.R. Br. J. Cancer (2003)
- Clinical relevance of urokinase-type plasminogen activator, its receptor, and its inhibitor type 1 in endometrial cancer. Tecimer, C., Doering, D.L., Goldsmith, L.J., Meyer, J.S., Abdulhay, G., Wittliff, J.L. Gynecol. Oncol. (2001)
- Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2. Pierson-Mullany, L.K., Lange, C.A. Mol. Cell. Biol. (2004)
- Phospho-serine-118 estrogen receptor-alpha expression is associated with better disease outcome in women treated with tamoxifen. Murphy, L.C., Niu, Y., Snell, L., Watson, P. Clin. Cancer Res. (2004)
- E1A-mediated repression of progesterone receptor-dependent transactivation involves inhibition of the assembly of a multisubunit coactivation complex. Xu, Y., Klein-Hitpass, L., Bagchi, M.K. Mol. Cell. Biol. (2000)
- Genetic instability and the development of steroid hormone insensitivity in cultured T 47D human breast cancer cells. Reddel, R.R., Alexander, I.E., Koga, M., Shine, J., Sutherland, R.L. Cancer Res. (1988)
- Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Järvinen, T.A., Pelto-Huikko, M., Holli, K., Isola, J. Am. J. Pathol. (2000)
- Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1. Chauchereau, A., Amazit, L., Quesne, M., Guiochon-Mantel, A., Milgrom, E. J. Biol. Chem. (2003)
- Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. Qi, C., Chang, J., Zhu, Y., Yeldandi, A.V., Rao, S.M., Zhu, Y.J. J. Biol. Chem. (2002)
- Functional interaction of hybrid response elements with wild-type and mutant steroid hormone receptors. Truss, M., Chalepakis, G., Slater, E.P., Mader, S., Beato, M. Mol. Cell. Biol. (1991)
- The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors. Verma, S., Ismail, A., Gao, X., Fu, G., Li, X., O'Malley, B.W., Nawaz, Z. Mol. Cell. Biol. (2004)
- Immunocytochemical localization of estrogen and progesterone receptor and prognosis in human primary breast cancer. Reiner, A., Neumeister, B., Spona, J., Reiner, G., Schemper, M., Jakesz, R. Cancer Res. (1990)
- Comparison of the short-term biological effects of 7alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17beta-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancer. Robertson, J.F., Nicholson, R.I., Bundred, N.J., Anderson, E., Rayter, Z., Dowsett, M., Fox, J.N., Gee, J.M., Webster, A., Wakeling, A.E., Morris, C., Dixon, M. Cancer Res. (2001)