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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Meningioma


High impact information on Meningioma


Chemical compound and disease context of Meningioma


Biological context of Meningioma


Anatomical context of Meningioma

  • The type of constitutional NF2 mutation is an important determinant of the number of NF2-associated intracranial meningiomas, spinal tumors, and peripheral nerve tumors [19].
  • In the immunoblot analysis, E-cadherin was detected at the main band of Mr 124,000 in all of the arachnoid villi, as well as syncytial and transitional types of meningiomas, but not in the fibroblastic type [20].
  • The present experiments were performed to evaluate whether the absence of ER from the majority of human meningioma cytosols can be attributed to: occurrence of only a small number of ER-positive cells in an otherwise ER-negative tissue; resistance of nuclear receptors to extraction; or impairment of steroid binding [21].
  • We have characterized the epidermal growth factor (EGF) receptor in human meningioma (biopsy) microsomes, cellularly derived microsomes, and intact meningioma cells in culture [22].
  • Media conditioned by cells cultured from six meningiomas also contained latent TGF beta-like activity [23].

Gene context of Meningioma


Analytical, diagnostic and therapeutic context of Meningioma


  1. Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin. Scoles, D.R., Huynh, D.P., Morcos, P.A., Coulsell, E.R., Robinson, N.G., Tamanoi, F., Pulst, S.M. Nat. Genet. (1998) [Pubmed]
  2. Meningiomas in lymphangioleiomyomatosis. Moss, J., DeCastro, R., Patronas, N.J., Taveira-DaSilva, A. JAMA (2001) [Pubmed]
  3. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. Berkman, R.A., Merrill, M.J., Reinhold, W.C., Monacci, W.T., Saxena, A., Clark, W.C., Robertson, J.T., Ali, I.U., Oldfield, E.H. J. Clin. Invest. (1993) [Pubmed]
  4. Inhibition of tumor-induced migration of bovine capillary endothelial cells by mouse and rabbit tumor necrosis factor. Mano-Hirano, Y., Sato, N., Sawasaki, Y., Haranaka, K., Satomi, N., Nariuchi, H., Goto, T. J. Natl. Cancer Inst. (1987) [Pubmed]
  5. Glioblastoma induction after radiosurgery for meningioma. Yu, J.S., Yong, W.H., Wilson, D., Black, K.L. Lancet (2000) [Pubmed]
  6. The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas. Kimura, Y., Koga, H., Araki, N., Mugita, N., Fujita, N., Takeshima, H., Nishi, T., Yamashima, T., Saido, T.C., Yamasaki, T., Moritake, K., Saya, H., Nakao, M. Nat. Med. (1998) [Pubmed]
  7. Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse. Kalamarides, M., Niwa-Kawakita, M., Leblois, H., Abramowski, V., Perricaudet, M., Janin, A., Thomas, G., Gutmann, D.H., Giovannini, M. Genes Dev. (2002) [Pubmed]
  8. Expression and localization of endothelin-1 and endothelin receptors in human meningiomas. Evidence for a role in tumoral growth. Pagotto, U., Arzberger, T., Hopfner, U., Sauer, J., Renner, U., Newton, C.J., Lange, M., Uhl, E., Weindl, A., Stalla, G.K. J. Clin. Invest. (1995) [Pubmed]
  9. Successful mifepristone treatment of recurrent, inoperable meningioma. Haak, H.R., de Keizer, R.J., Hagenouw-Taal, J.C., van Seters, A.P., Vielvoye, G.J., van Dulken, H. Lancet (1990) [Pubmed]
  10. Hydroxyurea for treatment of unresectable meningiomas. Schrell, U.M., Rittig, M.G., Koch, U., Marschalek, R., Anders, M. Lancet (1996) [Pubmed]
  11. Treatment of meningioma with octreotide. Rünzi, M.W., Jaspers, C., Windeck, R., Benker, G., Mehdorn, M., Reinhardt, V., Reinwein, D. Lancet (1989) [Pubmed]
  12. Simian virus 40-related antigens in three human meningiomas with defined chromosome loss. Weiss, A.F., Portmann, R., Fischer, H., Simon, J., Zang, K.D. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  13. Regulation of DNA synthesis and growth of cells derived from primary human meningiomas. Weisman, A.S., Villemure, J.G., Kelly, P.A. Cancer Res. (1986) [Pubmed]
  14. Benign and atypical meningioma metabolic signatures by high-resolution magic-angle spinning molecular profiling. Monleón, D., Morales, J.M., Gonzalez-Darder, J., Talamantes, F., Cortés, O., Gil-Benso, R., López-Ginés, C., Cerdá-Nicolás, M., Celda, B. J. Proteome Res. (2008) [Pubmed]
  15. Neurofibromatosis 2: loss of merlin's protective spell. Gusella, J.F., Ramesh, V., MacCollin, M., Jacoby, L.B. Curr. Opin. Genet. Dev. (1996) [Pubmed]
  16. Novel immunogenic antigen homologous to hyaluronidase in meningioma. Heckel, D., Comtesse, N., Brass, N., Blin, N., Zang, K.D., Meese, E. Hum. Mol. Genet. (1998) [Pubmed]
  17. cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients. Heckel, D., Brass, N., Fischer, U., Blin, N., Steudel, I., Türeci, O., Fackler, O., Zang, K.D., Meese, E. Hum. Mol. Genet. (1997) [Pubmed]
  18. Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q. Boström, J., Cobbers, J.M., Wolter, M., Tabatabai, G., Weber, R.G., Lichter, P., Collins, V.P., Reifenberger, G. Cancer Res. (1998) [Pubmed]
  19. Genotype-phenotype correlations for nervous system tumors in neurofibromatosis 2: a population-based study. Baser, M.E., Kuramoto, L., Joe, H., Friedman, J.M., Wallace, A.J., Gillespie, J.E., Ramsden, R.T., Evans, D.G. Am. J. Hum. Genet. (2004) [Pubmed]
  20. Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas. Tohma, Y., Yamashima, T., Yamashita, J. Cancer Res. (1992) [Pubmed]
  21. Search for estrogen receptors in human meningioma tissue sections with a monoclonal antibody against the human estrogen receptor. Blankenstein, M.A., Berns, P.M., Blaauw, G., Mulder, E., Thijssen, J.H. Cancer Res. (1986) [Pubmed]
  22. Characterization of the epidermal growth factor receptor in human meningioma. Weisman, A.S., Raguet, S.S., Kelly, P.A. Cancer Res. (1987) [Pubmed]
  23. Transforming growth factor-beta and transforming growth factor beta-receptor expression in human meningioma cells. Johnson, M.D., Federspiel, C.F., Gold, L.I., Moses, H.L. Am. J. Pathol. (1992) [Pubmed]
  24. Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors. Samoto, K., Ikezaki, K., Ono, M., Shono, T., Kohno, K., Kuwano, M., Fukui, M. Cancer Res. (1995) [Pubmed]
  25. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. Lusis, E.A., Watson, M.A., Chicoine, M.R., Lyman, M., Roerig, P., Reifenberger, G., Gutmann, D.H., Perry, A. Cancer Res. (2005) [Pubmed]
  26. Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors. Reubi, J.C., Schaer, J.C., Waser, B. Cancer Res. (1997) [Pubmed]
  27. Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cuevas, I.C., Slocum, A.L., Jun, P., Costello, J.F., Bollen, A.W., Riggins, G.J., McDermott, M.W., Lal, A. Cancer Res. (2005) [Pubmed]
  28. Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci. Elexpuru-Camiruaga, J., Buxton, N., Kandula, V., Dias, P.S., Campbell, D., McIntosh, J., Broome, J., Jones, P., Inskip, A., Alldersea, J. Cancer Res. (1995) [Pubmed]
  29. Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status. Goutagny, S., Yang, H.W., Zucman-Rossi, J., Chan, J., Dreyfuss, J.M., Park, P.J., Black, P.M., Giovannini, M., Carroll, R.S., Kalamarides, M. Clin. Cancer Res. (2010) [Pubmed]
  30. Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. Peyrard, M., Fransson, I., Xie, Y.G., Han, F.Y., Ruttledge, M.H., Swahn, S., Collins, J.E., Dunham, I., Collins, V.P., Dumanski, J.P. Hum. Mol. Genet. (1994) [Pubmed]
  31. Detection of activated platelet-derived growth factor receptors in human meningioma. Shamah, S.M., Alberta, J.A., Giannobile, W.V., Guha, A., Kwon, Y.K., Carroll, R.S., Black, P.M., Stiles, C.D. Cancer Res. (1997) [Pubmed]
  32. NF2 mutations in secretory and other rare variants of meningiomas. Hartmann, C., Sieberns, J., Gehlhaar, C., Simon, M., Paulus, W., von Deimling, A. Brain Pathol. (2006) [Pubmed]
  33. Anaplastic and atypical meningiomas express high levels of Fas and undergo apoptosis in response to Fas ligation. Weisberg, S., Ashkenazi, E., Israel, Z., Attia, M., Shoshan, Y., Umansky, F., Brodie, C. Am. J. Pathol. (2001) [Pubmed]
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