Gene Review:
HSD17B2 - hydroxysteroid (17-beta) dehydrogenase 2
Homo sapiens
Synonyms:
17-beta-HSD 2, 17-beta-hydroxysteroid dehydrogenase type 2, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, E2DH, ...
- Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions. Huber, A., Keck, C.C., Hefler, L.A., Schneeberger, C., Huber, J.C., Bentz, E.K., Tempfer, C.B. Obstetrics and gynecology. (2005)
- Estradiol 17 beta-hydroxysteroid dehydrogenase, a marker of breast cancer hormone dependency. Fournier, S., Brihmat, F., Durand, J.C., Sterkers, N., Martin, P.M., Kuttenn, F., Mauvais-Jarvis, P. Cancer Res. (1985)
- Biochemical characterization of 17 beta-hydroxysteroid dehydrogenase in human meningioma. Martin, P.M., Rieg, A.M., Fournier, S., Magdelenat, H., Hassoun, J., Pertuiset, B., Poisson, M., Vigouroux, R.P., Toga, M. Clinical neuropharmacology. (1984)
- Molecular cloning of cDNA for rat ovarian 20 alpha-hydroxysteroid dehydrogenase (HSD1). Miura, R., Shiota, K., Noda, K., Yagi, S., Ogawa, T., Takahashi, M. Biochem. J. (1994)
- Failure of progestins to induce estradiol dehydrogenase activity in endometrial carcinoma, in vitro. Satyaswaroop, P.G., Mortel, R. Cancer Res. (1982)
- The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21. Tonin, P., Serova, O., Simard, J., Lenoir, G., Feunteun, J., Morgan, K., Lynch, H., Narod, S. Hum. Mol. Genet. (1994)
- Loss of heterozygosity at 16q24.1-q24.2 is significantly associated with metastatic and aggressive behavior of prostate cancer. Elo, J.P., Härkönen, P., Kyllönen, A.P., Lukkarinen, O., Poutanen, M., Vihko, R., Vihko, P. Cancer Res. (1997)
- 17 beta-estradiol dehydrogenase (E2DH) activity in T47D cells. Malet, C., Vacca, A., Kuttenn, F., Mauvais-Jarvis, P. J. Steroid Biochem. Mol. Biol. (1991)
- Insulin-like growth factor type I and insulin-like growth factor type II stimulate oestradiol-17 beta hydroxysteroid dehydrogenase (reductive) activity in breast cancer cells. Singh, A., Reed, M.J. J. Endocrinol. (1991)
- Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2. Durocher, F., Morissette, J., Labrie, Y., Labrie, F., Simard, J. Genomics (1995)
- 17 beta-hydroxysteroid and 20 alpha-hydroxysteroid dehydrogenase activities of human placental microsomes: kinetic evidence for two enzymes differing in substrate specificity. Blomquist, C.H., Lindemann, N.J., Hakanson, E.Y. Arch. Biochem. Biophys. (1985)
- Characterization of two mRNA species encoding human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17. Labrie, F., Luu-The, V., Labrie, C., Bérubé, D., Couet, J., Zhao, H.F., Gagné, R., Simard, J. J. Steroid Biochem. (1989)
- Human ovarian expression of 17 beta-hydroxysteroid dehydrogenase types 1, 2, and 3. Zhang, Y., Word, R.A., Fesmire, S., Carr, B.R., Rainey, W.E. J. Clin. Endocrinol. Metab. (1996)
- Molecular expression of 17 beta hydroxysteroid dehydrogenase types in relation to their activity in intact human prostate cancer cells. Carruba, G., Adamski, J., Calabrò, M., Miceli, M.D., Cataliotti, A., Bellavia, V., Lo Bue, A., Polito, L., Castagnetta, L.A. Mol. Cell. Endocrinol. (1997)
- Androgen inactivation in human lung fibroblasts: variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen inactivation. Provost, P.R., Blomquist, C.H., Drolet, R., Flamand, N., Tremblay, Y. J. Clin. Endocrinol. Metab. (2002)
- 17 beta-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract. Sano, T., Hirasawa, G., Takeyama, J., Darnel, A.D., Suzuki, T., Moriya, T., Kato, K., Sekine, H., Ohara, S., Shimosegawa, T., Nakamura, J., Yoshihama, M., Harada, N., Sasano, H. Clin. Sci. (2001)
- Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity. Wu, L., Einstein, M., Geissler, W.M., Chan, H.K., Elliston, K.O., Andersson, S. J. Biol. Chem. (1993)
- Endometrial and pituitary responses to the steroidal antiprogestin RU 486 in postmenopausal women. Gravanis, A., Schaison, G., George, M., de Brux, J., Satyaswaroop, P.G., Baulieu, E.E., Robel, P. J. Clin. Endocrinol. Metab. (1985)
- Variants in Estrogen Biosynthesis Genes, Sex Steroid Hormone Levels, and Endometrial Cancer: A HuGE Review. Olson, S.H., Bandera, E.V., Orlow, I. Am. J. Epidemiol. (2007)
- Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme. Albiston, A.L., Obeyesekere, V.R., Smith, R.E., Krozowski, Z.S. Mol. Cell. Endocrinol. (1994)
- Study of human placental estradiol-17 beta dehydrogenase/20 alpha-hydroxysteroid dehydrogenase by preparative disc-gel electrophoresis. Tobias, B., Strickler, R.C. Steroids (1981)
- 20 alpha-Hydroxysteroid dehydrogenase and 17 beta-estradiol dehydrogenase localize in cytosol of human term placenta. Strickler, R.C., Tobias, B. Am. J. Physiol. (1982)
- Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity. Lacy, W.R., Washenick, K.J., Cook, R.G., Dunbar, B.S. Mol. Endocrinol. (1993)