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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genetic method for the preferential elimination of females of anopheles albimanus.

Recent field experiments demonstrated the possibility of using the sterile male method for the control of Anopheles albimanus Wiedemann, the most important vector of human malaria in Central America. Until now there was no practical method for excluding females from the releases of sterile males. A genetic method was developed for the preferential elimination of females during any of the four life stages. This genetic sexing system utilizes propoxur (o-isopropoxyphenyl methyl-carbamate) susceptibility as a recessive conditional lethal a T(Y:2R) translocation, and an In(2R)inversion. The propoxur resistance allele (dominant) was linked to the Y chromosome via a radiation-induced translocation, and genetic recombination was suppressed by inversions. In one of the strains produced, 99.7 percent of the females are eliminated when treated with propoxur, without male loss.[1]


  1. Genetic method for the preferential elimination of females of anopheles albimanus. Seawright, J.A., Kaiser, P.E., Dame, D.A., Lofgren, C.S. Science (1978) [Pubmed]
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