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Chemical Compound Review

Urethylane     methyl carbamate

Synonyms: Methylurethan, Methylkarbamat, methylcarbamat, H2NCOOCH3, LS-60, ...
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Disease relevance of methyl carbamate

  • Because of the potential of the majority of organophosphorous acid triesters and methylcarbamates to inhibit kynurenine formamidase, this novel noncholinergic mechanism warrants consideration in assessment of organophosphorous and methylcarbamate toxicity in occupational and accidental exposures [1].

High impact information on methyl carbamate


Biological context of methyl carbamate

  • The objective of this study was to examine the immunotoxicological effects of the methyl-carbamate pesticide carbaryl via the oral, dermal, or inhalation routes [7].
  • Since the macro- and microscopical cartilage alterations are significantly more frequent in the treated embryos than in the controls, a hypothesis is advanced that the methylcarbamate may increase the spontaneous tendency of the above mentioned cartilaginous anlagen to be affected by degenerative processes during embryogenesis [8].

Anatomical context of methyl carbamate


Analytical, diagnostic and therapeutic context of methyl carbamate


  1. Structural requirements for altering the L-tryptophan metabolism in mice by organophosphorous and methylcarbamate insecticides. Pewnim, T., Seifert, J. Eur. J. Pharmacol. (1993) [Pubmed]
  2. Isolation of a constitutively expressed enzyme for hydrolysis of carbaryl in Pseudomonas aeruginosa. Chapalmadugu, S., Chaudhry, G.R. J. Bacteriol. (1993) [Pubmed]
  3. Kynurenine formamidase inhibition as a possible mechanism for certain teratogenic effects of organophosphorus and methylcarbamate insecticides in chicken embryos. Moscioni, A.D., Engel, J.L., Casida, J.E. Biochem. Pharmacol. (1977) [Pubmed]
  4. Carbofuran-induced delayed neuropathy. Yang, P.Y., Tsao, T.C., Lin, J.L., Lyu, R.K., Chiang, P.C. J. Toxicol. Clin. Toxicol. (2000) [Pubmed]
  5. Organophosphorus pesticide-induced butyrylcholinesterase inhibition and potentiation of succinylcholine toxicity in mice. Sparks, S.E., Quistad, G.B., Casida, J.E. J. Biochem. Mol. Toxicol. (1999) [Pubmed]
  6. Determination of carbofuran, carbaryl and their main metabolites in plasma samples of agricultural populations using gas chromatography-tandem mass spectrometry. Petropoulou, S.S., Tsarbopoulos, A., Siskos, P.A. Analytical and bioanalytical chemistry. (2006) [Pubmed]
  7. Evaluation of the humoral immune response of CD rats following a 2-week exposure to the pesticide carbaryl by the oral, dermal, or inhalation routes. Ladics, G.S., Smith, C., Heaps, K., Loveless, S.E. Journal of toxicology and environmental health. (1994) [Pubmed]
  8. Methylcarbamate effects on Meckel's cartilages in the chick embryo. Virgintino, D., L'Abbate, N., Ribatti, D., Bertossi, M., Roncali, L., Ambrosi, L. Biological structures and morphogenesis. (1989) [Pubmed]
  9. Antibacterial activity and inhibition of protein synthesis in Escherichia coli by antisense DNA analogs. Rahman, M.A., Summerton, J., Foster, E., Cunningham, K., Stirchak, E., Weller, D., Schaup, H.W. Antisense Res. Dev. (1991) [Pubmed]
  10. Histological changes induced by the methyl-carbamate dinitro-octyl-phenol treatment in the small intestine and adrenal glands of white rats. Puică, C., Giurgea, R. Morphologie et embryologie. (1986) [Pubmed]
  11. Induction of carbofuran oxidation to 4-hydroxycarbofuran by Pseudomonas sp. 50432. Chaudhry, G.R., Mateen, A., Kaskar, B., Sardessai, M., Bloda, M., Bhatti, A.R., Walia, S.K. FEMS Microbiol. Lett. (2002) [Pubmed]
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