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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Non-renin-mediated renovascular hypertension: A new syndrome?

In two hypertensive patients with renal-artery stenosis, overactivity of the renin-angiotensin system was ruled out by investigations of renin and aldosterone concentrations and by the lack of a vasodepressor response to angiotensin blockade with saralasin. Nevertheless, hypertension was cured by renal revascularisation. The date suggest that there is a form of renovascular hypertension which is not mediated by the renin-angiotensin system.[1]


  1. Non-renin-mediated renovascular hypertension: A new syndrome? Marks, L.S., Maxwell, M.H., Kaufman, J.J. Lancet (1977) [Pubmed]
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