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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Renal Artery

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Disease relevance of Renal Artery


High impact information on Renal Artery

  • Unexpectedly, OPG-deficient mice also exhibit medial calcification of the aorta and renal arteries, suggesting that regulation of OPG, its signaling pathway, or its ligand(s) may play a role in the long observed association between osteoporosis and vascular calcification [6].
  • Diagnosis of unilateral renal artery lesions after captopril administration [7].
  • In the 18 patients who had a unilateral renal artery lesion demonstrated by angiography, the ratio of plasma renin activity of the involved to uninvolved renal vein rose significantly after administration of captopril, whether or not patients were taking antihypertensive medication [2].
  • An angiotensin II antagonist, sarcosine-1, threonine-8 angiotensin II ( [Sar1, Thr8] A II), was infused preoperatively in 14 patients with renal artery stenosis [8].
  • We infused microgram quantities of active or inactive PMN elastase and cathepsin G into the renal arteries of rats [9].

Chemical compound and disease context of Renal Artery


Biological context of Renal Artery


Anatomical context of Renal Artery


Associations of Renal Artery with chemical compounds


Gene context of Renal Artery

  • Although less prominent than the case for PDGF-A chain, PDGF-B chain also was present in medial and intimal smooth muscle cells in both rejecting and nonrejecting renal arteries [29].
  • Specific 125I-VEGF binding could be localized to renal arteries and veins, glomeruli, and the tubulointerstitial capillary network in different developmental stages [30].
  • Western blot test confirmed COX-2 expression in renal artery [31].
  • Histopathological analysis demonstrated significant renal artery disease in the form of extensive atheromatous plaques only in 7.5-month-old Apoe(-/-) mice, whereas no atherosclerotic lesions were found in 6-week-old Apoe(-/-) mice [32].
  • This agonist profile, together with the findings that the ETA receptor-selective antagonists, BQ-123 and FR-139317 caused concentration-dependent, rightward shifts of the concentration-effect curves to each agonist indicated that ET-1-induced contractions in rat renal artery were mediated via ETA receptors [33].

Analytical, diagnostic and therapeutic context of Renal Artery


  1. Inhibition of angiotensin-converting enzyme for diagnosis of renal-artery stenosis. Re, R., Novelline, R., Escourrou, M.T., Athanasoulis, C., Burton, J., Haber, E. N. Engl. J. Med. (1978) [Pubmed]
  2. Improved diagnosis of unilateral renal artery lesions after captopril administration. Thibonnier, M., Joseph, A., Sassano, P., Guyenne, T.T., Corvol, P., Raynaud, A., Seurot, M., Gaux, J.C. JAMA (1984) [Pubmed]
  3. Percutaneous transluminal angioplasty of the renal arteries. Levin, D.C. JAMA (1984) [Pubmed]
  4. Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat. Vukicevic, S., Basic, V., Rogic, D., Basic, N., Shih, M.S., Shepard, A., Jin, D., Dattatreyamurty, B., Jones, W., Dorai, H., Ryan, S., Griffiths, D., Maliakal, J., Jelic, M., Pastorcic, M., Stavljenic, A., Sampath, T.K. J. Clin. Invest. (1998) [Pubmed]
  5. Expression of two "immediate early" genes, Egr-1 and c-fos, in response to renal ischemia and during compensatory renal hypertrophy in mice. Ouellette, A.J., Malt, R.A., Sukhatme, V.P., Bonventre, J.V. J. Clin. Invest. (1990) [Pubmed]
  6. osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Bucay, N., Sarosi, I., Dunstan, C.R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H.L., Xu, W., Lacey, D.L., Boyle, W.J., Simonet, W.S. Genes Dev. (1998) [Pubmed]
  7. Diagnosis of unilateral renal artery lesions after captopril administration. Grim, C.E. JAMA (1985) [Pubmed]
  8. Predictive value of angiotensin II antagonists in renovascular hypertension. Fouad, F.M., Gifford, R.W., Fighali, S., Mujais, S.K., Novick, A.C., Bravo, E.L., Tarazi, R.C. JAMA (1983) [Pubmed]
  9. The human neutrophil serine proteinases, elastase and cathepsin G, can mediate glomerular injury in vivo. Johnson, R.J., Couser, W.G., Alpers, C.E., Vissers, M., Schulze, M., Klebanoff, S.J. J. Exp. Med. (1988) [Pubmed]
  10. Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. Fujino, T., Nakagawa, N., Yuhki, K., Hara, A., Yamada, T., Takayama, K., Kuriyama, S., Hosoki, Y., Takahata, O., Taniguchi, T., Fukuzawa, J., Hasebe, N., Kikuchi, K., Narumiya, S., Ushikubi, F. J. Clin. Invest. (2004) [Pubmed]
  11. Effect of renal-artery stenting on progression of renovascular renal failure. Harden, P.N., MacLeod, M.J., Rodger, R.S., Baxter, G.M., Connell, J.M., Dominiczak, A.F., Junor, B.J., Briggs, J.D., Moss, J.G. Lancet (1997) [Pubmed]
  12. Non-renin-mediated renovascular hypertension: A new syndrome? Marks, L.S., Maxwell, M.H., Kaufman, J.J. Lancet (1977) [Pubmed]
  13. Influence of the status of the renin-angiotensin system on the effect of cilazapril on neointima formation after vascular injury in rats. Clozel, J.P., Müller, R.K., Roux, S., Fischli, W., Baumgartner, H.R. Circulation (1993) [Pubmed]
  14. Chronic caffeine administration exacerbates renovascular, but not genetic, hypertension in rats. Ohnishi, A., Branch, R.A., Jackson, K., Hamilton, R., Biaggioni, I., Deray, G., Jackson, E.K. J. Clin. Invest. (1986) [Pubmed]
  15. A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat. Kon, V., Harris, R.C., Ichikawa, I. J. Clin. Invest. (1990) [Pubmed]
  16. Cytochrome P-450 mediates tissue-damaging hydroxyl radical formation during reoxygenation of the kidney. Paller, M.S., Jacob, H.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  17. Hypoperfusion-induced acute renal failure in the rat: an evaluation of oxidant tissue injury. Zager, R.A. Circ. Res. (1988) [Pubmed]
  18. Studies on the nature of a prostaglandin receptor in canine and rabbit vascular smooth muscle. Greenberg, S., Kadowitz, P.J., Long, J.P., Wilson, W.R. Circ. Res. (1976) [Pubmed]
  19. Increased production of nitric oxide in coronary arteries during congestive heart failure. O'Murchu, B., Miller, V.M., Perrella, M.A., Burnett, J.C. J. Clin. Invest. (1994) [Pubmed]
  20. Myocardial protection by brief ischemia in noncardiac tissue. Gho, B.C., Schoemaker, R.G., van den Doel, M.A., Duncker, D.J., Verdouw, P.D. Circulation (1996) [Pubmed]
  21. Contrast ultrasonography of the kidney: a new method for evaluation of renal perfusion in vivo. Lang, R.M., Feinstein, S.B., Powsner, S.M., McCoy, C.E., Frederickson, E.D., Neumann, A., Goldberg, L.I., Borow, K.M. Circulation (1987) [Pubmed]
  22. Effects of glycyl-L-glutamine and methylprednisolone on maintenance of acetylcholinesterase of transected rat sciatic nerves. Koelle, G.B., Han, M.S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  23. Beneficial effect of arachidonic acid during hemorrhagic shock in the dog. Flynn, J.T., Lefer, A.M. Circ. Res. (1977) [Pubmed]
  24. Urinary prostaglandins. Identification and origin. Frölich, J.C., Wilson, T.W., Sweetman, B.J., Smigel, M., Nies, A.S., Carr, K., Watson, J.T., Oates, J.A. J. Clin. Invest. (1975) [Pubmed]
  25. Prostaglandins mediate the vasodilatory effect of mannitol in the hypoperfused rat kidney. Johnston, P.A., Bernard, D.B., Perrin, N.S., Levinsky, N.G. J. Clin. Invest. (1981) [Pubmed]
  26. Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney. Scholz, H., Kurtz, A. J. Clin. Invest. (1993) [Pubmed]
  27. Differential regulation of renal phospholipase C isoforms by catecholamines. Yu, P.Y., Asico, L.D., Eisner, G.M., Jose, P.A. J. Clin. Invest. (1995) [Pubmed]
  28. New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system. Johnson, R.J., Couser, W.G., Chi, E.Y., Adler, S., Klebanoff, S.J. J. Clin. Invest. (1987) [Pubmed]
  29. Identification of platelet-derived growth factor A and B chains in human renal vascular rejection. Alpers, C.E., Davis, C.L., Barr, D., Marsh, C.L., Hudkins, K.L. Am. J. Pathol. (1996) [Pubmed]
  30. Receptors of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in fetal and adult human kidney: localization and [125I]VEGF binding sites. Simon, M., Röckl, W., Hornig, C., Gröne, E.F., Theis, H., Weich, H.A., Fuchs, E., Yayon, A., Gröne, H.J. J. Am. Soc. Nephrol. (1998) [Pubmed]
  31. Cycloxygenase-2 is expressed in vasculature of normal and ischemic adult human kidney and is colocalized with vascular prostaglandin E2 EP4 receptors. Therland, K.L., Stubbe, J., Thiesson, H.C., Ottosen, P.D., Walter, S., Sørensen, G.L., Skøtt, O., Jensen, B.L. J. Am. Soc. Nephrol. (2004) [Pubmed]
  32. Hypertension and endothelial dysfunction in apolipoprotein E knockout mice. Yang, R., Powell-Braxton, L., Ogaoawara, A.K., Dybdal, N., Bunting, S., Ohneda, O., Jin, H. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  33. Comparison of the contractile effects and binding kinetics of endothelin-1 and sarafotoxin S6b in rat isolated renal artery. Devadason, P.S., Henry, P.J. Br. J. Pharmacol. (1997) [Pubmed]
  34. Effects of acute unilateral renal denervation in the rat. Bello-Reuss, E., Colindres, R.E., Pastoriza-Muñoz, E., Mueller, R.A., Gottschalk, C.W. J. Clin. Invest. (1975) [Pubmed]
  35. Bioassay in vivo for circulating vasoactive agents after renal artery constriction in dogs. Pamnani, M.B., Simon, G., Overbeck, H.W. Circ. Res. (1976) [Pubmed]
  36. Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries. Kauser, K., Clark, J.E., Masters, B.S., Ortiz de Montellano, P.R., Ma, Y.H., Harder, D.R., Roman, R.J. Circ. Res. (1991) [Pubmed]
  37. Captopril renography in the diagnosis of renal artery stenosis: accuracy and limitations. Mann, S.J., Pickering, T.G., Sos, T.A., Uzzo, R.G., Sarkar, S., Friend, K., Rackson, M.E., Laragh, J.H. Am. J. Med. (1991) [Pubmed]
  38. Nitric oxide in ischaemic acute renal failure of streptozotocin diabetic rats. Goor, Y., Peer, G., Iaina, A., Blum, M., Wollman, Y., Chernihovsky, T., Silverberg, D., Cabili, S. Diabetologia (1996) [Pubmed]
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